{"id":13657,"date":"2022-12-01T15:36:00","date_gmt":"2022-12-01T15:36:00","guid":{"rendered":"https:\/\/www.ttci-th.org\/?p=13657"},"modified":"2023-06-24T16:08:46","modified_gmt":"2023-06-24T16:08:46","slug":"anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition","status":"publish","type":"post","link":"https:\/\/www.ttci-th.org\/th\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\/","title":{"rendered":"\u0e41\u0e2d\u0e19\u0e15\u0e34-CD19 \u0e44\u0e04\u0e40\u0e21\u0e2d\u0e23\u0e34\u0e01\u0e41\u0e2d\u0e19\u0e15\u0e34\u0e40\u0e08\u0e19\u0e23\u0e35\u0e40\u0e0b\u0e1e\u0e40\u0e15\u0e2d\u0e23\u0e4c\u0e17\u0e35\u0e40\u0e0b\u0e25\u0e25\u0e4c\u0e17\u0e35\u0e48\u0e04\u0e31\u0e14\u0e41\u0e22\u0e01\u0e0a\u0e34\u0e49\u0e19\u0e2a\u0e48\u0e27\u0e19\u0e17\u0e35\u0e48\u0e41\u0e1b\u0e23\u0e1c\u0e31\u0e19\u0e44\u0e14\u0e49\u0e2a\u0e32\u0e22\u0e40\u0e14\u0e35\u0e48\u0e22\u0e27\u0e02\u0e2d\u0e07\u0e41\u0e2d\u0e19\u0e15\u0e34-PD-L1 \u0e25\u0e14\u0e17\u0e2d\u0e19\u0e01\u0e32\u0e23\u0e22\u0e31\u0e1a\u0e22\u0e31\u0e49\u0e07\u0e17\u0e35\u0e40\u0e0b\u0e25\u0e25\u0e4c\u0e17\u0e35\u0e48\u0e21\u0e35\u0e2a\u0e37\u0e48\u0e2d\u0e01\u0e25\u0e32\u0e07 PD-L1"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"13657\" class=\"elementor elementor-13657\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9e9621b elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"9e9621b\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-218319c\" data-id=\"218319c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-f6d8091\" data-id=\"f6d8091\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-80dd4c1\" data-id=\"80dd4c1\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-4be962c\" data-id=\"4be962c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-21e348c elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"21e348c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.16.0 - 14-09-2023 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<div id=\"2BA85E87_4BC3_472E_41F0_2FF79C2C6F72\">Photo by Ivan Samkov\/pexels<\/div><div id=\"2BA85E87_4BC3_472E_41F0_2FF79C2C6F72\">\u00a0<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b9af823 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"b9af823\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2db16c3\" data-id=\"2db16c3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e57f26e elementor-widget elementor-widget-text-editor\" data-id=\"e57f26e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Researchers from Faculty of Medicine Siriraj Hospital, Mahidol University have developed a new type of chimeric antigen receptor T cell, known as anti-CD19-CAR5-T cells, which have shown promising results in combating B cell lymphomas. These cells demonstrated superior cytotoxicity compared to their predecessors, the anti-CD19-CAR4-T cells, particularly at a low effector-to-target ratio. The study found that the cytotoxicity of anti-CD19-CAR4-T cells was inhibited by the upregulation of PD-1 on CAR-T cells and PD-L1 on target cancer cells. However, the anti-CD19-CAR5-T cells, which secrete an anti-PD-L1 single-chain variable fragment (scFv), were able to restore the cytotoxic effect of the anti-CD19-CAR4-T cells. Additionally, the secreted anti-PD-L1 scFv promoted self-proliferation of the anti-CD19-CAR5-T cells. These findings suggest that PD-L1 blockade by anti-PD-L1 scFv secreted from CAR5-T cells could be a viable strategy to enhance the antitumor efficiency of CAR-T cell therapies.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e1b683c elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"e1b683c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fc1e61f\" data-id=\"fc1e61f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e0f513f elementor-widget elementor-widget-text-editor\" data-id=\"e0f513f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Lymphomas, predominantly of B cell origin, vary in their aggressiveness and response to chemotherapy. Despite the success of second-generation anti-CD19 chimeric antigen receptor T cells (anti-CD19-CAR2-T) in treating some B cell malignancies, their effectiveness against aggressive B cell lymphomas (BCL) has been limited. Researchers have now developed a fourth-generation CAR-T cell (CAR4-T cells) that includes three costimulatory domains, showing high cytotoxic activity against various tumor models. However, the PD-1\/PD-L1 interaction, which plays a crucial role in T cell suppression, remains a significant barrier to CAR-T cell therapy effectiveness. To overcome this, the researchers engineered anti-CD19-CAR4-T cells to secrete anti-PD-L1 single-chain variable fragment (scFv), creating anti-CD19-CAR5-T cells. These cells showed superior cytotoxic functions, cytokine secretion levels, and proliferation compared to anti-CD19-CAR4-T cells. Furthermore, they showed effective cytotoxicity against cancer cells expressing both CD19 and PD-L1, even at low effector-to-target ratios. This approach could potentially reduce treatment-related toxicity and costs. However, further in vivo studies and clinical trials are needed to confirm the safety and efficacy of anti-CD19-CAR5-T cells for treating aggressive BCL.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d777e2d elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"d777e2d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fbc0aee\" data-id=\"fbc0aee\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f42f7db elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"f42f7db\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.16.0 - 14-09-2023 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">\u0e40\u0e07\u0e34\u0e19\u0e17\u0e38\u0e19<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a3809f5 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"a3809f5\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.16.0 - 14-09-2023 *\/\n.elementor-widget-divider{--divider-border-style:none;--divider-border-width:1px;--divider-color:#0c0d0e;--divider-icon-size:20px;--divider-element-spacing:10px;--divider-pattern-height:24px;--divider-pattern-size:20px;--divider-pattern-url:none;--divider-pattern-repeat:repeat-x}.elementor-widget-divider .elementor-divider{display:flex}.elementor-widget-divider .elementor-divider__text{font-size:15px;line-height:1;max-width:95%}.elementor-widget-divider .elementor-divider__element{margin:0 var(--divider-element-spacing);flex-shrink:0}.elementor-widget-divider .elementor-icon{font-size:var(--divider-icon-size)}.elementor-widget-divider .elementor-divider-separator{display:flex;margin:0;direction:ltr}.elementor-widget-divider--view-line_icon .elementor-divider-separator,.elementor-widget-divider--view-line_text .elementor-divider-separator{align-items:center}.elementor-widget-divider--view-line_icon .elementor-divider-separator:after,.elementor-widget-divider--view-line_icon .elementor-divider-separator:before,.elementor-widget-divider--view-line_text .elementor-divider-separator:after,.elementor-widget-divider--view-line_text .elementor-divider-separator:before{display:block;content:\"\";border-bottom:0;flex-grow:1;border-top:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--element-align-left .elementor-divider .elementor-divider-separator>.elementor-divider__svg:first-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-left .elementor-divider-separator:before{content:none}.elementor-widget-divider--element-align-left .elementor-divider__element{margin-left:0}.elementor-widget-divider--element-align-right .elementor-divider .elementor-divider-separator>.elementor-divider__svg:last-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-right .elementor-divider-separator:after{content:none}.elementor-widget-divider--element-align-right .elementor-divider__element{margin-right:0}.elementor-widget-divider:not(.elementor-widget-divider--view-line_text):not(.elementor-widget-divider--view-line_icon) .elementor-divider-separator{border-top:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--separator-type-pattern{--divider-border-style:none}.elementor-widget-divider--separator-type-pattern.elementor-widget-divider--view-line .elementor-divider-separator,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:after,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:before,.elementor-widget-divider--separator-type-pattern:not([class*=elementor-widget-divider--view]) .elementor-divider-separator{width:100%;min-height:var(--divider-pattern-height);-webkit-mask-size:var(--divider-pattern-size) 100%;mask-size:var(--divider-pattern-size) 100%;-webkit-mask-repeat:var(--divider-pattern-repeat);mask-repeat:var(--divider-pattern-repeat);background-color:var(--divider-color);-webkit-mask-image:var(--divider-pattern-url);mask-image:var(--divider-pattern-url)}.elementor-widget-divider--no-spacing{--divider-pattern-size:auto}.elementor-widget-divider--bg-round{--divider-pattern-repeat:round}.rtl .elementor-widget-divider .elementor-divider__text{direction:rtl}.e-con-inner>.elementor-widget-divider,.e-con>.elementor-widget-divider{width:var(--container-widget-width,100%);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e1c8b36 elementor-widget elementor-widget-text-editor\" data-id=\"e1c8b36\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>This study was financially supported by grants from the National Science and Technology Development Agency (NSTDA) (grant number P1650727); Mahidol University (grant numbers R016110006 and R016210017); the Program Management Unit for National Competitiveness Enhancement (PMU-C) under the Office of National Higher Education Science Research and Innovation Policy Council (NXPO) (grant number C10F630063); Siriraj Research Fund of the Faculty of Medicine Siriraj Hospital, (grant number R016034008); the International Research Network (IRN) and the Thailand Research Fund (TRF) (grant number IRN58W0001). YW was supported by an International Research Network (IRN)-Ph.D. Scholarship (IRN5801PHDW01). PYu was supported by the Faculty of Medicine Siriraj Hospital, Mahidol University.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a3c7bb6 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"a3c7bb6\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e51aa36\" data-id=\"e51aa36\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-61b459f elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"61b459f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\n\u0e01\u0e23\u0e30\u0e14\u0e32\u0e29\u0e15\u0e49\u0e19\u0e09\u0e1a\u0e31\u0e1a<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e2c38ec elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"e2c38ec\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f7592ce elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"f7592ce\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>\u0e0a\u0e37\u0e48\u0e2d\u0e1a\u0e17\u0e04\u0e27\u0e32\u0e21\u0e15\u0e49\u0e19\u0e09\u0e1a\u0e31\u0e1a:<\/strong> \u0e41\u0e2d\u0e19\u0e15\u0e34-CD19 \u0e44\u0e04\u0e40\u0e21\u0e2d\u0e23\u0e34\u0e01\u0e41\u0e2d\u0e19\u0e15\u0e34\u0e40\u0e08\u0e19\u0e23\u0e35\u0e40\u0e0b\u0e1e\u0e40\u0e15\u0e2d\u0e23\u0e4c\u0e17\u0e35\u0e40\u0e0b\u0e25\u0e25\u0e4c\u0e17\u0e35\u0e48\u0e04\u0e31\u0e14\u0e41\u0e22\u0e01\u0e0a\u0e34\u0e49\u0e19\u0e2a\u0e48\u0e27\u0e19\u0e17\u0e35\u0e48\u0e41\u0e1b\u0e23\u0e1c\u0e31\u0e19\u0e44\u0e14\u0e49\u0e2a\u0e32\u0e22\u0e40\u0e14\u0e35\u0e48\u0e22\u0e27\u0e02\u0e2d\u0e07\u0e41\u0e2d\u0e19\u0e15\u0e34-PD-L1 \u0e25\u0e14\u0e17\u0e2d\u0e19\u0e01\u0e32\u0e23\u0e22\u0e31\u0e1a\u0e22\u0e31\u0e49\u0e07\u0e17\u0e35\u0e40\u0e0b\u0e25\u0e25\u0e4c\u0e17\u0e35\u0e48\u0e21\u0e35\u0e2a\u0e37\u0e48\u0e2d\u0e01\u0e25\u0e32\u0e07 PD-L1<br \/><strong>\u0e27\u0e32\u0e23\u0e2a\u0e32\u0e23: <\/strong><span class=\"anchor-text\">International Immunopharmacology<br \/><\/span><strong>\u0e14\u0e2d\u0e22: <\/strong><a class=\"anchor doi anchor-default anchor-external-link\" title=\"Persistent link using digital object identifier\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1567576922009274?via%3Dihub\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"Persistent link using digital object identifier\"><span class=\"anchor-text\">10.1016\/j.intimp.2022.109442<\/span><\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5c5d082 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"5c5d082\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d7e3d8d\" data-id=\"d7e3d8d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8a45000 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"8a45000\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u0e08\u0e14\u0e2b\u0e21\u0e32\u0e22\u0e42\u0e15\u0e49\u0e15\u0e2d\u0e1a<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ef3890 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"8ef3890\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8df055a elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"8df055a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><a href=\"https:\/\/sites.google.com\/view\/sicore-cit\/about-us\/staff\/a_pa-thai-yenchitsomanus\"><span class=\"given-name\">\u0e1c\u0e31\u0e14\u0e44\u0e17<\/span>\u00a0<\/a><span class=\"text surname\"><a href=\"https:\/\/sites.google.com\/view\/sicore-cit\/about-us\/staff\/a_pa-thai-yenchitsomanus\">\u0e40\u0e22\u0e47\u0e19\u0e08\u0e34\u0e15\u0e42\u0e2a\u0e21\u0e19\u0e31\u0e2a<\/a>, <a href=\"https:\/\/sites.google.com\/view\/sicore-cit\/about-us\/staff\/r_jatuporn-sujjitjoon\"><span class=\"given-name\">Jatuporn<\/span>\u00a0Sujjitjoon<\/a><\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f4a8ca1 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"f4a8ca1\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-37e423b\" data-id=\"37e423b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d86aba3 elementor-widget elementor-widget-jkit_social_share\" data-id=\"d86aba3\" data-element_type=\"widget\" data-widget_type=\"jkit_social_share.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div  class=\"jeg-elementor-kit jkit-social-share jeg_module___6abf2edaf3ee8\" ><ul class=\"social-share-list\"><li class=\"elementor-repeater-item-14d1b21\" data-social=\"facebook\">\n\t\t\t\t<a class=\"facebook social-icon\"><span class=\"icon-position-before\"><i aria-hidden=\"true\" class=\"fab fa-facebook-f\"><\/i>\u0e40\u0e1f\u0e2a\u0e1a\u0e38\u0e4a\u0e04<\/span><\/a>\n\t\t\t<\/li><li class=\"elementor-repeater-item-ee9a855\" data-social=\"twitter\">\n\t\t\t\t<a class=\"twitter social-icon\"><span class=\"icon-position-before\"><i aria-hidden=\"true\" class=\"fab fa-twitter\"><\/i>\u0e17\u0e27\u0e34\u0e15\u0e40\u0e15\u0e2d\u0e23\u0e4c<\/span><\/a>\n\t\t\t<\/li><li class=\"elementor-repeater-item-4a6d796\" data-social=\"line\">\n\t\t\t\t<a class=\"line social-icon\"><span class=\"icon-position-before\"><i aria-hidden=\"true\" class=\"fab fa-line\"><\/i>\u0e40\u0e2a\u0e49\u0e19<\/span><\/a>\n\t\t\t<\/li><\/ul><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Photo by Ivan Samkov\/pexels\u00a0 Researchers from Faculty of Medicine Siriraj Hospital, Mahidol University have developed a new type of chimeric antigen receptor T cell, known as anti-CD19-CAR5-T cells, which have shown promising results in combating B cell lymphomas. These cells demonstrated superior cytotoxicity compared to their predecessors, the anti-CD19-CAR4-T cells, particularly at a low effector-to-target&#8230;<\/p>","protected":false},"author":2,"featured_media":14362,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[105],"tags":[102],"class_list":["post-13657","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-news-research-news","tag-tag-news-mu"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.2 - aioseo.com -->\n\t<meta name=\"description\" content=\"Researchers from Faculty of Medicine Siriraj Hospital, Mahidol University have developed a new type of chimeric antigen receptor T cell, known as anti-CD19-CAR5-T cells, w\u2026\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"admin\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.ttci-th.org\/th\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 5.0.2\" \/>\n\t\t<meta property=\"og:locale\" content=\"th_TH\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Thailand Hub of Talents in Cancer Immunotherapy (TTCI Thailand) - TTCI-TH\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"Anti-CD19 chimeric antigen receptor T cells secreting anti-PD-L1 single-chain variable fragment attenuate PD-L1 mediated T cell inhibition\" \/>\n\t\t<meta property=\"og:description\" content=\"Researchers from Faculty of Medicine Siriraj Hospital, Mahidol University have developed a new type of chimeric antigen receptor T cell, known as anti-CD19-CAR5-T cells, w\u2026\" \/>\n\t\t<meta property=\"og:url\" content=\"https:\/\/www.ttci-th.org\/th\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\/\" \/>\n\t\t<meta property=\"og:image\" content=\"https:\/\/www.ttci-th.org\/wp-content\/uploads\/2022\/12\/pexels-ivan-samkov-9629684-scaled.jpg\" \/>\n\t\t<meta property=\"og:image:secure_url\" content=\"https:\/\/www.ttci-th.org\/wp-content\/uploads\/2022\/12\/pexels-ivan-samkov-9629684-scaled.jpg\" \/>\n\t\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t\t<meta property=\"og:image:height\" content=\"1707\" \/>\n\t\t<meta property=\"article:published_time\" content=\"2022-12-01T15:36:00+00:00\" \/>\n\t\t<meta property=\"article:modified_time\" content=\"2023-06-24T16:08:46+00:00\" \/>\n\t\t<meta property=\"article:publisher\" content=\"https:\/\/web.facebook.com\/ttci.th\/\" \/>\n\t\t<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n\t\t<meta name=\"twitter:site\" content=\"@ttci_th\" \/>\n\t\t<meta name=\"twitter:title\" content=\"Anti-CD19 chimeric antigen receptor T cells secreting anti-PD-L1 single-chain variable fragment attenuate PD-L1 mediated T cell inhibition\" \/>\n\t\t<meta name=\"twitter:description\" content=\"Researchers from Faculty of Medicine Siriraj Hospital, Mahidol University have developed a new type of chimeric antigen receptor T cell, known as anti-CD19-CAR5-T cells, w\u2026\" \/>\n\t\t<meta name=\"twitter:creator\" content=\"@ttci_th\" \/>\n\t\t<meta name=\"twitter:image\" content=\"https:\/\/www.ttci-th.org\/wp-content\/uploads\/2022\/12\/pexels-ivan-samkov-9629684-scaled.jpg\" \/>\n\t\t<script type=\"application\/ld+json\" class=\"aioseo-schema\">\n\t\t\t{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"BlogPosting\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\\\/#blogposting\",\"name\":\"Anti-CD19 chimeric antigen receptor T cells secreting anti-PD-L1 single-chain variable fragment attenuate PD-L1 mediated T cell inhibition - Thailand Hub of Talents in Cancer Immunotherapy (TTCI Thailand)\",\"headline\":\"Anti-CD19 chimeric antigen receptor T cells secreting anti-PD-L1 single-chain variable fragment attenuate PD-L1 mediated T cell inhibition\",\"author\":{\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/author\\\/admin\\\/#author\"},\"publisher\":{\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/#organization\"},\"image\":{\"@type\":\"ImageObject\",\"url\":\"https:\\\/\\\/www.ttci-th.org\\\/wp-content\\\/uploads\\\/2022\\\/12\\\/pexels-ivan-samkov-9629684-scaled.jpg\",\"width\":2560,\"height\":1707},\"datePublished\":\"2022-12-01T15:36:00+00:00\",\"dateModified\":\"2023-06-24T16:08:46+00:00\",\"inLanguage\":\"th\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\\\/#webpage\"},\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\\\/#webpage\"},\"articleSection\":\"Mahidol University, Mahidol University\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\\\/#breadcrumblist\",\"itemListElement\":[{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/#listItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/category\\\/research-news\\\/#listItem\",\"name\":\"Research News\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/category\\\/research-news\\\/#listItem\",\"position\":2,\"name\":\"Research News\",\"item\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/category\\\/research-news\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/category\\\/research-news\\\/research-news-research-news\\\/#listItem\",\"name\":\"Mahidol University\"},\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/#listItem\",\"name\":\"Home\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/category\\\/research-news\\\/research-news-research-news\\\/#listItem\",\"position\":3,\"name\":\"Mahidol University\",\"item\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/category\\\/research-news\\\/research-news-research-news\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\\\/#listItem\",\"name\":\"Anti-CD19 chimeric antigen receptor T cells secreting anti-PD-L1 single-chain variable fragment attenuate PD-L1 mediated T cell inhibition\"},\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/category\\\/research-news\\\/#listItem\",\"name\":\"Research News\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\\\/#listItem\",\"position\":4,\"name\":\"Anti-CD19 chimeric antigen receptor T cells secreting anti-PD-L1 single-chain variable fragment attenuate PD-L1 mediated T cell inhibition\",\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/category\\\/research-news\\\/research-news-research-news\\\/#listItem\",\"name\":\"Mahidol University\"}}]},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/#organization\",\"name\":\"Thailand Hub of Talents in Cancer Immunotherapy\",\"description\":\"TTCI-TH\",\"url\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"url\":\"https:\\\/\\\/www.ttci-th.org\\\/wp-content\\\/uploads\\\/2023\\\/05\\\/cropped-cropped-TTCI_LOGO__PNG_-001-removebg-preview.png\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\\\/#organizationLogo\",\"width\":512,\"height\":512},\"image\":{\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\\\/#organizationLogo\"},\"sameAs\":[\"https:\\\/\\\/web.facebook.com\\\/ttci.th\\\/\",\"https:\\\/\\\/www.twitter.com\\\/ttci_th\\\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/author\\\/admin\\\/#author\",\"url\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/author\\\/admin\\\/\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\\\/#authorImage\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/5b85cd0b211a9025509530deb5346a2678862327550dd3ffa569f013791940ac?s=96&d=mm&r=g\",\"width\":96,\"height\":96,\"caption\":\"admin\"}},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\\\/#webpage\",\"url\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\\\/\",\"name\":\"Anti-CD19 chimeric antigen receptor T cells secreting anti-PD-L1 single-chain variable fragment attenuate PD-L1 mediated T cell inhibition - Thailand Hub of Talents in Cancer Immunotherapy (TTCI Thailand)\",\"description\":\"Researchers from Faculty of Medicine Siriraj Hospital, Mahidol University have developed a new type of chimeric antigen receptor T cell, known as anti-CD19-CAR5-T cells, w\\u2026\",\"inLanguage\":\"th\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/#website\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\\\/#breadcrumblist\"},\"author\":{\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/author\\\/admin\\\/#author\"},\"creator\":{\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/author\\\/admin\\\/#author\"},\"image\":{\"@type\":\"ImageObject\",\"url\":\"https:\\\/\\\/www.ttci-th.org\\\/wp-content\\\/uploads\\\/2022\\\/12\\\/pexels-ivan-samkov-9629684-scaled.jpg\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\\\/#mainImage\",\"width\":2560,\"height\":1707},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\\\/#mainImage\"},\"datePublished\":\"2022-12-01T15:36:00+00:00\",\"dateModified\":\"2023-06-24T16:08:46+00:00\"},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/#website\",\"url\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/\",\"name\":\"Thailand Hub of Talents in Cancer Immunotherapy\",\"description\":\"TTCI-TH\",\"inLanguage\":\"th\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/#organization\"}}]}\n\t\t<\/script>\n\t\t<!-- All in One SEO -->\n\n","aioseo_head_json":{"title":"Anti-CD19 chimeric antigen receptor T cells secreting anti-PD-L1 single-chain variable fragment attenuate PD-L1 mediated T cell inhibition - Thailand Hub of Talents in Cancer Immunotherapy (TTCI Thailand)","description":"Researchers from Faculty of Medicine Siriraj Hospital, Mahidol University have developed a new type of chimeric antigen receptor T cell, known as anti-CD19-CAR5-T cells, w\u2026","canonical_url":"https:\/\/www.ttci-th.org\/th\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\/","robots":"max-image-preview:large","keywords":"","webmasterTools":{"miscellaneous":""},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"BlogPosting","@id":"https:\/\/www.ttci-th.org\/th\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\/#blogposting","name":"Anti-CD19 chimeric antigen receptor T cells secreting anti-PD-L1 single-chain variable fragment attenuate PD-L1 mediated T cell inhibition - Thailand Hub of Talents in Cancer Immunotherapy (TTCI Thailand)","headline":"Anti-CD19 chimeric antigen receptor T cells secreting anti-PD-L1 single-chain variable fragment attenuate PD-L1 mediated T cell inhibition","author":{"@id":"https:\/\/www.ttci-th.org\/th\/author\/admin\/#author"},"publisher":{"@id":"https:\/\/www.ttci-th.org\/th\/#organization"},"image":{"@type":"ImageObject","url":"https:\/\/www.ttci-th.org\/wp-content\/uploads\/2022\/12\/pexels-ivan-samkov-9629684-scaled.jpg","width":2560,"height":1707},"datePublished":"2022-12-01T15:36:00+00:00","dateModified":"2023-06-24T16:08:46+00:00","inLanguage":"th","mainEntityOfPage":{"@id":"https:\/\/www.ttci-th.org\/th\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\/#webpage"},"isPartOf":{"@id":"https:\/\/www.ttci-th.org\/th\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\/#webpage"},"articleSection":"Mahidol University, Mahidol University"},{"@type":"BreadcrumbList","@id":"https:\/\/www.ttci-th.org\/th\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\/#breadcrumblist","itemListElement":[{"@type":"ListItem","@id":"https:\/\/www.ttci-th.org\/th\/#listItem","position":1,"name":"Home","item":"https:\/\/www.ttci-th.org\/th\/","nextItem":{"@type":"ListItem","@id":"https:\/\/www.ttci-th.org\/th\/category\/research-news\/#listItem","name":"Research News"}},{"@type":"ListItem","@id":"https:\/\/www.ttci-th.org\/th\/category\/research-news\/#listItem","position":2,"name":"Research News","item":"https:\/\/www.ttci-th.org\/th\/category\/research-news\/","nextItem":{"@type":"ListItem","@id":"https:\/\/www.ttci-th.org\/th\/category\/research-news\/research-news-research-news\/#listItem","name":"Mahidol University"},"previousItem":{"@type":"ListItem","@id":"https:\/\/www.ttci-th.org\/th\/#listItem","name":"Home"}},{"@type":"ListItem","@id":"https:\/\/www.ttci-th.org\/th\/category\/research-news\/research-news-research-news\/#listItem","position":3,"name":"Mahidol University","item":"https:\/\/www.ttci-th.org\/th\/category\/research-news\/research-news-research-news\/","nextItem":{"@type":"ListItem","@id":"https:\/\/www.ttci-th.org\/th\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\/#listItem","name":"Anti-CD19 chimeric antigen receptor T cells secreting anti-PD-L1 single-chain variable fragment attenuate PD-L1 mediated T cell inhibition"},"previousItem":{"@type":"ListItem","@id":"https:\/\/www.ttci-th.org\/th\/category\/research-news\/#listItem","name":"Research News"}},{"@type":"ListItem","@id":"https:\/\/www.ttci-th.org\/th\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\/#listItem","position":4,"name":"Anti-CD19 chimeric antigen receptor T cells secreting anti-PD-L1 single-chain variable fragment attenuate PD-L1 mediated T cell inhibition","previousItem":{"@type":"ListItem","@id":"https:\/\/www.ttci-th.org\/th\/category\/research-news\/research-news-research-news\/#listItem","name":"Mahidol University"}}]},{"@type":"Organization","@id":"https:\/\/www.ttci-th.org\/th\/#organization","name":"Thailand Hub of Talents in Cancer Immunotherapy","description":"TTCI-TH","url":"https:\/\/www.ttci-th.org\/th\/","logo":{"@type":"ImageObject","url":"https:\/\/www.ttci-th.org\/wp-content\/uploads\/2023\/05\/cropped-cropped-TTCI_LOGO__PNG_-001-removebg-preview.png","@id":"https:\/\/www.ttci-th.org\/th\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\/#organizationLogo","width":512,"height":512},"image":{"@id":"https:\/\/www.ttci-th.org\/th\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\/#organizationLogo"},"sameAs":["https:\/\/web.facebook.com\/ttci.th\/","https:\/\/www.twitter.com\/ttci_th\/"]},{"@type":"Person","@id":"https:\/\/www.ttci-th.org\/th\/author\/admin\/#author","url":"https:\/\/www.ttci-th.org\/th\/author\/admin\/","name":"admin","image":{"@type":"ImageObject","@id":"https:\/\/www.ttci-th.org\/th\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\/#authorImage","url":"https:\/\/secure.gravatar.com\/avatar\/5b85cd0b211a9025509530deb5346a2678862327550dd3ffa569f013791940ac?s=96&d=mm&r=g","width":96,"height":96,"caption":"admin"}},{"@type":"WebPage","@id":"https:\/\/www.ttci-th.org\/th\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\/#webpage","url":"https:\/\/www.ttci-th.org\/th\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\/","name":"Anti-CD19 chimeric antigen receptor T cells secreting anti-PD-L1 single-chain variable fragment attenuate PD-L1 mediated T cell inhibition - Thailand Hub of Talents in Cancer Immunotherapy (TTCI Thailand)","description":"Researchers from Faculty of Medicine Siriraj Hospital, Mahidol University have developed a new type of chimeric antigen receptor T cell, known as anti-CD19-CAR5-T cells, w\u2026","inLanguage":"th","isPartOf":{"@id":"https:\/\/www.ttci-th.org\/th\/#website"},"breadcrumb":{"@id":"https:\/\/www.ttci-th.org\/th\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\/#breadcrumblist"},"author":{"@id":"https:\/\/www.ttci-th.org\/th\/author\/admin\/#author"},"creator":{"@id":"https:\/\/www.ttci-th.org\/th\/author\/admin\/#author"},"image":{"@type":"ImageObject","url":"https:\/\/www.ttci-th.org\/wp-content\/uploads\/2022\/12\/pexels-ivan-samkov-9629684-scaled.jpg","@id":"https:\/\/www.ttci-th.org\/th\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\/#mainImage","width":2560,"height":1707},"primaryImageOfPage":{"@id":"https:\/\/www.ttci-th.org\/th\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\/#mainImage"},"datePublished":"2022-12-01T15:36:00+00:00","dateModified":"2023-06-24T16:08:46+00:00"},{"@type":"WebSite","@id":"https:\/\/www.ttci-th.org\/th\/#website","url":"https:\/\/www.ttci-th.org\/th\/","name":"Thailand Hub of Talents in Cancer Immunotherapy","description":"TTCI-TH","inLanguage":"th","publisher":{"@id":"https:\/\/www.ttci-th.org\/th\/#organization"}}]},"og:locale":"th_TH","og:site_name":"Thailand Hub of Talents in Cancer Immunotherapy (TTCI Thailand) - TTCI-TH","og:type":"article","og:title":"Anti-CD19 chimeric antigen receptor T cells secreting anti-PD-L1 single-chain variable fragment attenuate PD-L1 mediated T cell inhibition","og:description":"Researchers from Faculty of Medicine Siriraj Hospital, Mahidol University have developed a new type of chimeric antigen receptor T cell, known as anti-CD19-CAR5-T cells, w\u2026","og:url":"https:\/\/www.ttci-th.org\/th\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\/","og:image":"https:\/\/www.ttci-th.org\/wp-content\/uploads\/2022\/12\/pexels-ivan-samkov-9629684-scaled.jpg","og:image:secure_url":"https:\/\/www.ttci-th.org\/wp-content\/uploads\/2022\/12\/pexels-ivan-samkov-9629684-scaled.jpg","og:image:width":"2560","og:image:height":"1707","article:published_time":"2022-12-01T15:36:00+00:00","article:modified_time":"2023-06-24T16:08:46+00:00","article:publisher":"https:\/\/web.facebook.com\/ttci.th\/","twitter:card":"summary_large_image","twitter:site":"@ttci_th","twitter:title":"Anti-CD19 chimeric antigen receptor T cells secreting anti-PD-L1 single-chain variable fragment attenuate PD-L1 mediated T cell inhibition","twitter:description":"Researchers from Faculty of Medicine Siriraj Hospital, Mahidol University have developed a new type of chimeric antigen receptor T cell, known as anti-CD19-CAR5-T cells, w\u2026","twitter:creator":"@ttci_th","twitter:image":"https:\/\/www.ttci-th.org\/wp-content\/uploads\/2022\/12\/pexels-ivan-samkov-9629684-scaled.jpg"},"aioseo_meta_data":{"post_id":"13657","title":null,"description":"Researchers from Faculty of Medicine Siriraj Hospital, Mahidol University have developed a new type of chimeric antigen receptor T cell, known as anti-CD19-CAR5-T cells, w\u2026","keywords":[],"keyphrases":{"focus":{"keyphrase":"Anti-CD19","score":76,"analysis":{"keyphraseInTitle":{"score":9,"maxScore":9,"error":0},"keyphraseInDescription":{"score":9,"maxScore":9,"error":0},"keyphraseLength":{"score":9,"maxScore":9,"error":0,"length":1},"keyphraseInURL":{"score":5,"maxScore":5,"error":0},"keyphraseInIntroduction":{"score":3,"maxScore":9,"error":1},"keyphraseInSubHeadings":{"score":3,"maxScore":9,"error":1},"keyphraseInImageAlt":[]}},"additional":[]},"primary_term":null,"canonical_url":null,"og_title":"#post_title","og_description":"Researchers from Faculty of Medicine Siriraj Hospital, Mahidol University have developed a new type of chimeric antigen receptor T cell, known as anti-CD19-CAR5-T cells, w\u2026","og_object_type":"default","og_image_type":"featured","og_image_url":"https:\/\/www.ttci-th.org\/wp-content\/uploads\/2022\/12\/pexels-ivan-samkov-9629684-scaled.jpg","og_image_width":"2560","og_image_height":"1707","og_image_custom_url":null,"og_image_custom_fields":null,"og_video":"","og_custom_url":null,"og_article_section":null,"og_article_tags":[],"twitter_use_og":false,"twitter_card":"default","twitter_image_type":"featured","twitter_image_url":"https:\/\/www.ttci-th.org\/wp-content\/uploads\/2022\/12\/pexels-ivan-samkov-9629684-scaled.jpg","twitter_image_custom_url":null,"twitter_image_custom_fields":null,"twitter_title":"#post_title","twitter_description":"Researchers from Faculty of Medicine Siriraj Hospital, Mahidol University have developed a new type of chimeric antigen receptor T cell, known as anti-CD19-CAR5-T cells, w\u2026","schema":{"blockGraphs":[],"customGraphs":[],"default":{"data":{"Article":[],"Course":[],"Dataset":[],"FAQPage":[],"Movie":[],"Person":[],"Product":[],"ProductReview":[],"Car":[],"Recipe":[],"Service":[],"SoftwareApplication":[],"WebPage":[]},"graphName":"","isEnabled":true},"graphs":[]},"schema_type":"default","schema_type_options":null,"pillar_content":false,"robots_default":true,"robots_noindex":false,"robots_noarchive":false,"robots_nosnippet":false,"robots_nofollow":false,"robots_noimageindex":false,"robots_noodp":false,"robots_notranslate":false,"robots_max_snippet":"-1","robots_max_videopreview":"-1","robots_max_imagepreview":"large","priority":0,"frequency":"default","local_seo":null,"limit_modified_date":false,"created":"2023-06-07 17:52:00","updated":"2026-09-03 06:44:19","focus_keyword":"Anti-CD19","additional_keywords":null,"truseo_locale":null,"ai":null,"breadcrumb_settings":null,"seo_analyzer_scan_date":null},"aioseo_breadcrumb":"<div class=\"aioseo-breadcrumbs\"><span class=\"aioseo-breadcrumb\">\n\t\t\t<a href=\"https:\/\/www.ttci-th.org\/th\/\" title=\"Home\">Home<\/a>\n\t\t<\/span><span class=\"aioseo-breadcrumb-separator\">\u00bb<\/span><span class=\"aioseo-breadcrumb\">\n\t\t\t<a href=\"https:\/\/www.ttci-th.org\/th\/category\/research-news\/\" title=\"Research News\">Research News<\/a>\n\t\t<\/span><span class=\"aioseo-breadcrumb-separator\">\u00bb<\/span><span class=\"aioseo-breadcrumb\">\n\t\t\t<a href=\"https:\/\/www.ttci-th.org\/th\/category\/research-news\/research-news-research-news\/\" title=\"Mahidol University\">Mahidol University<\/a>\n\t\t<\/span><span class=\"aioseo-breadcrumb-separator\">\u00bb<\/span><span class=\"aioseo-breadcrumb\">\n\t\t\tAnti-CD19 chimeric antigen receptor T cells secreting anti-PD-L1 single-chain variable fragment attenuate PD-L1 mediated T cell inhibition\n\t\t<\/span><\/div>","aioseo_breadcrumb_json":[{"label":"Home","link":"https:\/\/www.ttci-th.org\/th\/"},{"label":"Research News","link":"https:\/\/www.ttci-th.org\/th\/category\/research-news\/"},{"label":"Mahidol University","link":"https:\/\/www.ttci-th.org\/th\/category\/research-news\/research-news-research-news\/"},{"label":"Anti-CD19 chimeric antigen receptor T cells secreting anti-PD-L1 single-chain variable fragment attenuate PD-L1 mediated T cell inhibition","link":"https:\/\/www.ttci-th.org\/th\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition\/"}],"_links":{"self":[{"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/posts\/13657","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/comments?post=13657"}],"version-history":[{"count":0,"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/posts\/13657\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/media\/14362"}],"wp:attachment":[{"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/media?parent=13657"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/categories?post=13657"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/tags?post=13657"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}