{"id":13670,"date":"2023-02-01T15:57:57","date_gmt":"2023-02-01T15:57:57","guid":{"rendered":"https:\/\/www.ttci-th.org\/?p=13670"},"modified":"2023-06-24T16:02:51","modified_gmt":"2023-06-24T16:02:51","slug":"anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition-2","status":"publish","type":"post","link":"https:\/\/www.ttci-th.org\/th\/anti-cd19-chimeric-antigen-receptor-t-cells-secreting-anti-pd-l1-single-chain-variable-fragment-attenuate-pd-l1-mediated-t-cell-inhibition-2\/","title":{"rendered":"\u0e01\u0e32\u0e23\u0e1a\u0e33\u0e1a\u0e31\u0e14\u0e14\u0e49\u0e27\u0e22 T-Cell \u0e40\u0e0a\u0e34\u0e07\u0e27\u0e34\u0e28\u0e27\u0e01\u0e23\u0e23\u0e21\u0e41\u0e1a\u0e1a\u0e43\u0e2b\u0e21\u0e48: Anti-Mucin 1 Chimeric Antigen Receptor \u0e17\u0e35\u0e40\u0e0b\u0e25\u0e25\u0e4c\u0e17\u0e35\u0e48\u0e41\u0e2a\u0e14\u0e07\u0e2d\u0e2d\u0e01 PD-1-CD28 Switch Receptor \u0e41\u0e2a\u0e14\u0e07\u0e43\u0e2b\u0e49\u0e40\u0e2b\u0e47\u0e19\u0e16\u0e36\u0e07\u0e04\u0e33\u0e21\u0e31\u0e48\u0e19\u0e2a\u0e31\u0e0d\u0e0d\u0e32\u0e43\u0e19\u0e01\u0e32\u0e23\u0e15\u0e48\u0e2d\u0e2a\u0e39\u0e49\u0e01\u0e31\u0e1a\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e17\u0e48\u0e2d\u0e19\u0e49\u0e33\u0e14\u0e35\u0e17\u0e35\u0e48\u0e16\u0e36\u0e07\u0e41\u0e01\u0e48\u0e0a\u0e35\u0e27\u0e34\u0e15"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"13670\" class=\"elementor elementor-13670\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9e9621b elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"9e9621b\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-218319c\" data-id=\"218319c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-f6d8091\" data-id=\"f6d8091\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-80dd4c1\" data-id=\"80dd4c1\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-4be962c\" data-id=\"4be962c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-21e348c elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"21e348c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.16.0 - 14-09-2023 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>Image by Chokniti Khongchum\/pexels<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9d4695d elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"9d4695d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c6c93db\" data-id=\"c6c93db\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5001b41 elementor-widget elementor-widget-text-editor\" data-id=\"5001b41\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>A team of researchers from Faculty of Medicine Siriraj Hospital, Mahidol University, has made a significant stride in the fight against cholangiocarcinoma (CCA), a highly lethal form of bile-duct cancer that has proven difficult to treat using conventional methods. The team focused on developing an innovative approach called adoptive T-cell therapy, which harnesses the power of the body&#8217;s immune system to target and destroy cancer cells.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7c36597 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"7c36597\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a3d8b3f\" data-id=\"a3d8b3f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c0fd6a3 elementor-widget elementor-widget-text-editor\" data-id=\"c0fd6a3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Their breakthrough lies in the creation of anti-MUC1 chimeric antigen receptor (CAR) T cells, designed to specifically target a protein called MUC1 that is overexpressed in CCA cells. However, MUC1 overexpression also triggers the activation of PD-L1, an immune checkpoint protein that hampers the anti-tumor functions of T cells, leading to poor patient outcomes.<\/p><p>To overcome this hurdle, the researchers developed a novel type of T-cell called \u03b1M.CAR\/SR T cells, which not only target MUC1 but also possess a PD-1-CD28 switch receptor (SR). This switch receptor activates CD28 signaling while inhibiting the PD-1\/PD-L1 interaction, thereby unleashing the full potential of the T cells against the cancer cells.<\/p><p>In their experiments, the researchers found that \u03b1M.CAR\/SR T cells exhibited a significant increase in cytotoxic activity compared to regular \u03b1M.CAR T cells. The \u03b1M.CAR\/SR T cells showed enhanced production of tumor necrosis factor-\u03b1 and interferon-\u03b3, two potent anti-cancer molecules, in response to CCA cells expressing MUC1. Notably, \u03b1M.CAR\/SR T cells demonstrated a remarkable ability to target CCA cells expressing PD-L1, leading to improved cancer cell destruction and increased production of granzyme B, a key molecule involved in killing cancer cells.<\/p><p>These findings pave the way for further testing and development of \u03b1M.CAR\/SR T cells as a potential treatment option for cholangiocarcinoma. This groundbreaking research brings hope to patients and clinicians alike, offering a potential breakthrough in the battle against this devastating form of cancer.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7f24289 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"7f24289\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0a32a30\" data-id=\"0a32a30\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3e5b349 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"3e5b349\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.16.0 - 14-09-2023 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">\u0e40\u0e07\u0e34\u0e19\u0e17\u0e38\u0e19<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-085fdc7 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"085fdc7\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.16.0 - 14-09-2023 *\/\n.elementor-widget-divider{--divider-border-style:none;--divider-border-width:1px;--divider-color:#0c0d0e;--divider-icon-size:20px;--divider-element-spacing:10px;--divider-pattern-height:24px;--divider-pattern-size:20px;--divider-pattern-url:none;--divider-pattern-repeat:repeat-x}.elementor-widget-divider .elementor-divider{display:flex}.elementor-widget-divider .elementor-divider__text{font-size:15px;line-height:1;max-width:95%}.elementor-widget-divider .elementor-divider__element{margin:0 var(--divider-element-spacing);flex-shrink:0}.elementor-widget-divider .elementor-icon{font-size:var(--divider-icon-size)}.elementor-widget-divider .elementor-divider-separator{display:flex;margin:0;direction:ltr}.elementor-widget-divider--view-line_icon .elementor-divider-separator,.elementor-widget-divider--view-line_text .elementor-divider-separator{align-items:center}.elementor-widget-divider--view-line_icon .elementor-divider-separator:after,.elementor-widget-divider--view-line_icon .elementor-divider-separator:before,.elementor-widget-divider--view-line_text .elementor-divider-separator:after,.elementor-widget-divider--view-line_text .elementor-divider-separator:before{display:block;content:\"\";border-bottom:0;flex-grow:1;border-top:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--element-align-left .elementor-divider .elementor-divider-separator>.elementor-divider__svg:first-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-left .elementor-divider-separator:before{content:none}.elementor-widget-divider--element-align-left .elementor-divider__element{margin-left:0}.elementor-widget-divider--element-align-right .elementor-divider .elementor-divider-separator>.elementor-divider__svg:last-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-right .elementor-divider-separator:after{content:none}.elementor-widget-divider--element-align-right .elementor-divider__element{margin-right:0}.elementor-widget-divider:not(.elementor-widget-divider--view-line_text):not(.elementor-widget-divider--view-line_icon) .elementor-divider-separator{border-top:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--separator-type-pattern{--divider-border-style:none}.elementor-widget-divider--separator-type-pattern.elementor-widget-divider--view-line .elementor-divider-separator,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:after,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:before,.elementor-widget-divider--separator-type-pattern:not([class*=elementor-widget-divider--view]) .elementor-divider-separator{width:100%;min-height:var(--divider-pattern-height);-webkit-mask-size:var(--divider-pattern-size) 100%;mask-size:var(--divider-pattern-size) 100%;-webkit-mask-repeat:var(--divider-pattern-repeat);mask-repeat:var(--divider-pattern-repeat);background-color:var(--divider-color);-webkit-mask-image:var(--divider-pattern-url);mask-image:var(--divider-pattern-url)}.elementor-widget-divider--no-spacing{--divider-pattern-size:auto}.elementor-widget-divider--bg-round{--divider-pattern-repeat:round}.rtl .elementor-widget-divider .elementor-divider__text{direction:rtl}.e-con-inner>.elementor-widget-divider,.e-con>.elementor-widget-divider{width:var(--container-widget-width,100%);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fe5ba79 elementor-widget elementor-widget-text-editor\" data-id=\"fe5ba79\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>This work was supported by the Siriraj Research Fund, Faculty of Medicine Siriraj Hospital, Mahidol University (grant nos. R016034008 and R016334002), Mahidol University (grant nos. R015810005 and R016110006), and International Research Network (IRN) (IRN58W0001), Thailand Research Fund (TRF). KS and TS were formerly supported by IRN Scholarships (IRN5801PHDW04 and IRN5801PHDW02) and Siriraj Graduate Scholarships, Faculty of Medicine Siriraj Hospital, Mahidol University. MJ was supported by Siriraj Chalermphrakiat Grant.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a3c7bb6 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"a3c7bb6\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e51aa36\" data-id=\"e51aa36\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-61b459f elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"61b459f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\n\u0e01\u0e23\u0e30\u0e14\u0e32\u0e29\u0e15\u0e49\u0e19\u0e09\u0e1a\u0e31\u0e1a<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e2c38ec elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"e2c38ec\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f7592ce elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"f7592ce\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>\u0e0a\u0e37\u0e48\u0e2d\u0e1a\u0e17\u0e04\u0e27\u0e32\u0e21\u0e15\u0e49\u0e19\u0e09\u0e1a\u0e31\u0e1a:<\/strong> Cytotoxic activity of anti-mucin 1 chimeric antigen receptor T cells expressing PD-1-CD28 switch receptor against cholangiocarcinoma cells<br \/><strong>\u0e27\u0e32\u0e23\u0e2a\u0e32\u0e23: <\/strong>Cytotherapy<br \/><strong>\u0e14\u0e2d\u0e22: <\/strong><span class=\"identifier doi\"><a class=\"id-link\" href=\"http:\/\/10.1016\/j.jcyt.2022.10.006\" target=\"_blank\" rel=\"noopener\" data-ga-category=\"full_text\" data-ga-action=\"DOI\">10.1016\/j.jcyt.2022.10.006<\/a><\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5c5d082 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"5c5d082\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d7e3d8d\" data-id=\"d7e3d8d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8a45000 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"8a45000\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u0e08\u0e14\u0e2b\u0e21\u0e32\u0e22\u0e42\u0e15\u0e49\u0e15\u0e2d\u0e1a<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ef3890 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"8ef3890\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8df055a elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"8df055a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><a href=\"https:\/\/sites.google.com\/view\/sicore-cit\/about-us\/staff\/a_pa-thai-yenchitsomanus\"><span class=\"given-name\">\u0e1c\u0e31\u0e14\u0e44\u0e17<\/span>\u00a0<\/a><span class=\"text surname\"><a href=\"https:\/\/sites.google.com\/view\/sicore-cit\/about-us\/staff\/a_pa-thai-yenchitsomanus\">\u0e40\u0e22\u0e47\u0e19\u0e08\u0e34\u0e15\u0e42\u0e2a\u0e21\u0e19\u0e31\u0e2a<\/a>, <a href=\"https:\/\/sites.google.com\/view\/sicore-cit\/about-us\/staff\/a_mutita-junking\">\u0e21\u0e38\u0e17\u0e34\u0e15\u0e32 \u0e08\u0e38\u0e25\u0e01\u0e34\u0e48\u0e07<\/a><\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e7dbafa elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"e7dbafa\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d91d717\" data-id=\"d91d717\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fe3ea78 elementor-widget elementor-widget-jkit_social_share\" data-id=\"fe3ea78\" data-element_type=\"widget\" data-widget_type=\"jkit_social_share.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div  class=\"jeg-elementor-kit jkit-social-share jeg_module___6a2e635a0641e\" ><ul class=\"social-share-list\"><li class=\"elementor-repeater-item-14d1b21\" data-social=\"facebook\">\n\t\t\t\t<a class=\"facebook social-icon\"><span class=\"icon-position-before\"><i aria-hidden=\"true\" class=\"fab fa-facebook-f\"><\/i>\u0e40\u0e1f\u0e2a\u0e1a\u0e38\u0e4a\u0e04<\/span><\/a>\n\t\t\t<\/li><li class=\"elementor-repeater-item-ee9a855\" data-social=\"twitter\">\n\t\t\t\t<a class=\"twitter social-icon\"><span class=\"icon-position-before\"><i aria-hidden=\"true\" class=\"fab fa-twitter\"><\/i>\u0e17\u0e27\u0e34\u0e15\u0e40\u0e15\u0e2d\u0e23\u0e4c<\/span><\/a>\n\t\t\t<\/li><li class=\"elementor-repeater-item-4a6d796\" data-social=\"line\">\n\t\t\t\t<a class=\"line social-icon\"><span class=\"icon-position-before\"><i aria-hidden=\"true\" class=\"fab fa-line\"><\/i>\u0e40\u0e2a\u0e49\u0e19<\/span><\/a>\n\t\t\t<\/li><\/ul><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Image by Chokniti Khongchum\/pexels A team of researchers from Faculty of Medicine Siriraj Hospital, Mahidol University, has made a significant stride in the fight against cholangiocarcinoma (CCA), a highly lethal form of bile-duct cancer that has proven difficult to treat using conventional methods. The team focused on developing an innovative approach called adoptive T-cell therapy,&#8230;<\/p>","protected":false},"author":2,"featured_media":14330,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[105],"tags":[102],"class_list":["post-13670","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-news-research-news","tag-tag-news-mu"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/posts\/13670","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/comments?post=13670"}],"version-history":[{"count":0,"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/posts\/13670\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/media\/14330"}],"wp:attachment":[{"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/media?parent=13670"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/categories?post=13670"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/tags?post=13670"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}