{"id":14450,"date":"2022-03-01T10:06:47","date_gmt":"2022-03-01T10:06:47","guid":{"rendered":"https:\/\/www.ttci-th.org\/?p=14450"},"modified":"2023-06-24T15:54:40","modified_gmt":"2023-06-24T15:54:40","slug":"antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma","status":"publish","type":"post","link":"https:\/\/www.ttci-th.org\/th\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\/","title":{"rendered":"\u0e01\u0e32\u0e23\u0e21\u0e35\u0e24\u0e17\u0e18\u0e34\u0e4c\u0e15\u0e49\u0e32\u0e19\u0e40\u0e19\u0e37\u0e49\u0e2d\u0e07\u0e2d\u0e01\u0e02\u0e2d\u0e07\u0e17\u0e35\u0e40\u0e0b\u0e25\u0e25\u0e4c\u0e17\u0e35\u0e48\u0e04\u0e31\u0e14\u0e15\u0e31\u0e27\u0e08\u0e31\u0e1a\u0e17\u0e35\u0e40\u0e0b\u0e25\u0e25\u0e4c\u0e17\u0e35\u0e48\u0e21\u0e35\u0e04\u0e27\u0e32\u0e21\u0e08\u0e33\u0e40\u0e1e\u0e32\u0e30\u0e41\u0e1a\u0e1a\u0e04\u0e39\u0e48 \u03b1CD133-\u03b1CD3 \u0e17\u0e35\u0e48\u0e15\u0e49\u0e32\u0e19\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e17\u0e48\u0e2d\u0e19\u0e49\u0e33\u0e14\u0e35"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"14450\" class=\"elementor elementor-14450\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9e9621b elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"9e9621b\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-218319c\" data-id=\"218319c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-f6d8091\" data-id=\"f6d8091\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-80dd4c1\" data-id=\"80dd4c1\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-4be962c\" data-id=\"4be962c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-21e348c elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"21e348c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.16.0 - 14-09-2023 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<div id=\"2BA85E87_4BC3_472E_41F0_2FF79C2C6F72\">Photo by Chokniti Khongchum\/pexels<\/div><div id=\"2BA85E87_4BC3_472E_41F0_2FF79C2C6F72\">\u00a0<\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b9af823 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"b9af823\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2db16c3\" data-id=\"2db16c3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e57f26e elementor-widget elementor-widget-text-editor\" data-id=\"e57f26e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>In a significant breakthrough for the treatment of cholangiocarcinoma (CCA), a highly lethal cancer of the bile duct epithelial cells, researchers have developed a novel therapeutic option using engineered T cells. With limited treatment options and a high mortality rate associated with CCA, this research offers hope for improved outcomes and potentially revolutionizing patient care.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e1b683c elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"e1b683c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fc1e61f\" data-id=\"fc1e61f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e0f513f elementor-widget elementor-widget-text-editor\" data-id=\"e0f513f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>The study, led by a team of scientists from Faculty of Medicine Siriraj Hospital, Mahidol University focused on targeting CD133-expressing CCA cells, which are known to contribute to tumor growth and resistance to current therapies. The researchers engineered T cells to secrete \u03b1CD133-\u03b1CD3 bispecific T-cell engagers, molecules capable of simultaneously binding CD133 on cancer cells and CD3 on T cells, triggering an immune response against the tumor cells.<\/p><p>To evaluate the effectiveness of this new therapeutic approach, the cDNA encoding the \u03b1CD133-\u03b1CD3 bispecific T-cell engager was cloned into a lentiviral construct and expressed in T cells obtained from healthy donors. The engineered T cells were then tested for their antitumor activity against CD133-expressing CCA cells.<\/p><p>The results of the study demonstrated promising antitumor effects of the engineered T cells. In co-culture systems, the T cells secreting \u03b1CD133-\u03b1CD3 engager exhibited significantly higher cytolytic activity against CD133-expressing CCA cells compared to untransduced T cells. At an effector-to-target ratio of 5:1, the engineered T cells showed cytolytic activity of 49.0\u00b19.76% and 64.10\u00b113.18% against KKU-100 and KKU-213A CCA cells, respectively, compared to only 10.97\u00b110.65% and 9.80\u00b111.05% for untransduced T cells.<\/p><p>Importantly, the secreted \u03b1CD133-\u03b1CD3 engager not only enhanced the killing activity of the engineered T cells but also redirected bystander T cells to attack the target CCA cells. The combination of transduced and bystander T cells resulted in a remarkable 73.20\u00b11.68% cytolytic activity against CCA cells, demonstrating the potential for a potent immune response.<\/p><p>Furthermore, the engineered T cells and bystander T cells exhibited enhanced killing activity against CCA spheroids, three-dimensional structures that mimic tumor behavior, with a rate approximately five times higher than the control condition without treatment.<\/p><p>These findings provide compelling proof-of-principle that T cells secreting \u03b1CD133-\u03b1CD3 engager hold promise as an alternative therapeutic approach for CD133-positive CCA. The successful preclinical results pave the way for further investigation in animal models and future clinical trials, bringing hope for a much-needed effective treatment option for CCA patients.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d777e2d elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"d777e2d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fbc0aee\" data-id=\"fbc0aee\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f42f7db elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"f42f7db\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.16.0 - 14-09-2023 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">\u0e40\u0e07\u0e34\u0e19\u0e17\u0e38\u0e19<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a3809f5 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"a3809f5\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.16.0 - 14-09-2023 *\/\n.elementor-widget-divider{--divider-border-style:none;--divider-border-width:1px;--divider-color:#0c0d0e;--divider-icon-size:20px;--divider-element-spacing:10px;--divider-pattern-height:24px;--divider-pattern-size:20px;--divider-pattern-url:none;--divider-pattern-repeat:repeat-x}.elementor-widget-divider .elementor-divider{display:flex}.elementor-widget-divider .elementor-divider__text{font-size:15px;line-height:1;max-width:95%}.elementor-widget-divider .elementor-divider__element{margin:0 var(--divider-element-spacing);flex-shrink:0}.elementor-widget-divider .elementor-icon{font-size:var(--divider-icon-size)}.elementor-widget-divider .elementor-divider-separator{display:flex;margin:0;direction:ltr}.elementor-widget-divider--view-line_icon .elementor-divider-separator,.elementor-widget-divider--view-line_text .elementor-divider-separator{align-items:center}.elementor-widget-divider--view-line_icon .elementor-divider-separator:after,.elementor-widget-divider--view-line_icon .elementor-divider-separator:before,.elementor-widget-divider--view-line_text .elementor-divider-separator:after,.elementor-widget-divider--view-line_text .elementor-divider-separator:before{display:block;content:\"\";border-bottom:0;flex-grow:1;border-top:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--element-align-left .elementor-divider .elementor-divider-separator>.elementor-divider__svg:first-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-left .elementor-divider-separator:before{content:none}.elementor-widget-divider--element-align-left .elementor-divider__element{margin-left:0}.elementor-widget-divider--element-align-right .elementor-divider .elementor-divider-separator>.elementor-divider__svg:last-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-right .elementor-divider-separator:after{content:none}.elementor-widget-divider--element-align-right .elementor-divider__element{margin-right:0}.elementor-widget-divider:not(.elementor-widget-divider--view-line_text):not(.elementor-widget-divider--view-line_icon) .elementor-divider-separator{border-top:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--separator-type-pattern{--divider-border-style:none}.elementor-widget-divider--separator-type-pattern.elementor-widget-divider--view-line .elementor-divider-separator,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:after,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:before,.elementor-widget-divider--separator-type-pattern:not([class*=elementor-widget-divider--view]) .elementor-divider-separator{width:100%;min-height:var(--divider-pattern-height);-webkit-mask-size:var(--divider-pattern-size) 100%;mask-size:var(--divider-pattern-size) 100%;-webkit-mask-repeat:var(--divider-pattern-repeat);mask-repeat:var(--divider-pattern-repeat);background-color:var(--divider-color);-webkit-mask-image:var(--divider-pattern-url);mask-image:var(--divider-pattern-url)}.elementor-widget-divider--no-spacing{--divider-pattern-size:auto}.elementor-widget-divider--bg-round{--divider-pattern-repeat:round}.rtl .elementor-widget-divider .elementor-divider__text{direction:rtl}.e-con-inner>.elementor-widget-divider,.e-con>.elementor-widget-divider{width:var(--container-widget-width,100%);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e1c8b36 elementor-widget elementor-widget-text-editor\" data-id=\"e1c8b36\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>PY was supported by grants from the International Research Network (grant numbers IRN58W0001) and the Siriraj Research Fund of the Faculty of Medicine Siriraj Hospital, Mahidol University (grant numbers R016034008 and R016334002). TS was supported by a grant from the International Research Network (grant numbers IRN5801PHDW02). KS was supported by a grant from the International Research Network (grant number IRN5801PHDW04). MJ was supported by a Siriraj Chalermphrakiat Grant from the Faculty of Medicine Siriraj Hospital, Mahidol University and Specific League Funds from Mahidol University. The funders have played no role in the research. There was no additional external funding received for this study.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a3c7bb6 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"a3c7bb6\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e51aa36\" data-id=\"e51aa36\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-61b459f elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"61b459f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\n\u0e01\u0e23\u0e30\u0e14\u0e32\u0e29\u0e15\u0e49\u0e19\u0e09\u0e1a\u0e31\u0e1a<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e2c38ec elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"e2c38ec\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f7592ce elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"f7592ce\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>\u0e0a\u0e37\u0e48\u0e2d\u0e1a\u0e17\u0e04\u0e27\u0e32\u0e21\u0e15\u0e49\u0e19\u0e09\u0e1a\u0e31\u0e1a:<\/strong> \u0e01\u0e32\u0e23\u0e21\u0e35\u0e24\u0e17\u0e18\u0e34\u0e4c\u0e15\u0e49\u0e32\u0e19\u0e40\u0e19\u0e37\u0e49\u0e2d\u0e07\u0e2d\u0e01\u0e02\u0e2d\u0e07\u0e17\u0e35\u0e40\u0e0b\u0e25\u0e25\u0e4c\u0e17\u0e35\u0e48\u0e04\u0e31\u0e14\u0e15\u0e31\u0e27\u0e08\u0e31\u0e1a\u0e17\u0e35\u0e40\u0e0b\u0e25\u0e25\u0e4c\u0e17\u0e35\u0e48\u0e21\u0e35\u0e04\u0e27\u0e32\u0e21\u0e08\u0e33\u0e40\u0e1e\u0e32\u0e30\u0e41\u0e1a\u0e1a\u0e04\u0e39\u0e48 \u03b1CD133-\u03b1CD3 \u0e17\u0e35\u0e48\u0e15\u0e49\u0e32\u0e19\u0e21\u0e30\u0e40\u0e23\u0e47\u0e07\u0e17\u0e48\u0e2d\u0e19\u0e49\u0e33\u0e14\u0e35<br \/><strong>\u0e27\u0e32\u0e23\u0e2a\u0e32\u0e23: <\/strong>PLoS One<span class=\"anchor-text\"><br \/><\/span><strong>\u0e14\u0e2d\u0e22: <\/strong><a href=\"http:\/\/10.1371\/journal.pone.0265773\">10.1371\/journal.pone.0265773<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d96249a elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"d96249a\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3f13380\" data-id=\"3f13380\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-490a2b5 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"490a2b5\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u0e08\u0e14\u0e2b\u0e21\u0e32\u0e22\u0e42\u0e15\u0e49\u0e15\u0e2d\u0e1a<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c252356 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"c252356\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2556c35 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"2556c35\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span class=\"text surname\">&nbsp;<a href=\"https:\/\/sites.google.com\/view\/sicore-cit\/about-us\/staff\/a_mutita-junking\">\u0e21\u0e38\u0e17\u0e34\u0e15\u0e32 \u0e08\u0e31\u0e07\u0e01\u0e34\u0e07, <\/a><a href=\"https:\/\/sites.google.com\/view\/sicore-cit\/about-us\/staff\/a_pa-thai-yenchitsomanus\"><span class=\"given-name\">\u0e1c\u0e31\u0e14\u0e44\u0e17<\/span>&nbsp;<\/a><a href=\"https:\/\/sites.google.com\/view\/sicore-cit\/about-us\/staff\/a_pa-thai-yenchitsomanus\">\u0e40\u0e22\u0e47\u0e19\u0e08\u0e34\u0e15\u0e42\u0e2a\u0e21\u0e19\u0e31\u0e2a<\/a><\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0e94bb0 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"0e94bb0\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a78f0f4\" data-id=\"a78f0f4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-46206bd elementor-widget__width-initial elementor-widget elementor-widget-jkit_social_share\" data-id=\"46206bd\" data-element_type=\"widget\" data-widget_type=\"jkit_social_share.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div  class=\"jeg-elementor-kit jkit-social-share jeg_module___6abf1e12e76cd\" ><ul class=\"social-share-list\"><li class=\"elementor-repeater-item-14d1b21\" data-social=\"facebook\">\n\t\t\t\t<a class=\"facebook social-icon\"><span class=\"icon-position-before\"><i aria-hidden=\"true\" class=\"fab fa-facebook-f\"><\/i>\u0e40\u0e1f\u0e2a\u0e1a\u0e38\u0e4a\u0e04<\/span><\/a>\n\t\t\t<\/li><li class=\"elementor-repeater-item-ee9a855\" data-social=\"twitter\">\n\t\t\t\t<a class=\"twitter social-icon\"><span class=\"icon-position-before\"><i aria-hidden=\"true\" class=\"fab fa-twitter\"><\/i>\u0e17\u0e27\u0e34\u0e15\u0e40\u0e15\u0e2d\u0e23\u0e4c<\/span><\/a>\n\t\t\t<\/li><li class=\"elementor-repeater-item-4a6d796\" data-social=\"line\">\n\t\t\t\t<a class=\"line social-icon\"><span class=\"icon-position-before\"><i aria-hidden=\"true\" class=\"fab fa-line\"><\/i>\u0e40\u0e2a\u0e49\u0e19<\/span><\/a>\n\t\t\t<\/li><\/ul><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Photo by Chokniti Khongchum\/pexels\u00a0 In a significant breakthrough for the treatment of cholangiocarcinoma (CCA), a highly lethal cancer of the bile duct epithelial cells, researchers have developed a novel therapeutic option using engineered T cells. With limited treatment options and a high mortality rate associated with CCA, this research offers hope for improved outcomes and&#8230;<\/p>","protected":false},"author":2,"featured_media":14452,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[105],"tags":[102],"class_list":["post-14450","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-news-research-news","tag-tag-news-mu"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.2 - aioseo.com -->\n\t<meta name=\"description\" content=\"Photo by Chokniti Khongchum\/pexels In a significant breakthrough for the treatment of cholangiocarcinoma (CCA), a highly lethal cancer of the bile duct epithelial cells, researchers have developed a novel therapeutic option using engineered T cells. With limited treatment options and a high mortality rate associated with CCA, this research offers hope for improved outcomes and\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"admin\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.ttci-th.org\/th\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 5.0.2\" \/>\n\t\t<meta property=\"og:locale\" content=\"th_TH\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Thailand Hub of Talents in Cancer Immunotherapy (TTCI Thailand) - TTCI-TH\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"Antitumor activity of T cells secreting \u03b1CD133-\u03b1CD3 bispecific T-cell engager against cholangiocarcinoma\" \/>\n\t\t<meta property=\"og:description\" content=\"In a significant breakthrough for the treatment of cholangiocarcinoma (CCA), a highly lethal cancer of the bile duct epithelial cells,\" \/>\n\t\t<meta property=\"og:url\" content=\"https:\/\/www.ttci-th.org\/th\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\/\" \/>\n\t\t<meta property=\"og:image\" content=\"https:\/\/www.ttci-th.org\/wp-content\/uploads\/2022\/03\/pexels-chokniti-khongchum-2280571-scaled.jpg\" \/>\n\t\t<meta property=\"og:image:secure_url\" content=\"https:\/\/www.ttci-th.org\/wp-content\/uploads\/2022\/03\/pexels-chokniti-khongchum-2280571-scaled.jpg\" \/>\n\t\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t\t<meta property=\"og:image:height\" content=\"1709\" \/>\n\t\t<meta property=\"article:published_time\" content=\"2022-03-01T10:06:47+00:00\" \/>\n\t\t<meta property=\"article:modified_time\" content=\"2023-06-24T15:54:40+00:00\" \/>\n\t\t<meta property=\"article:publisher\" content=\"https:\/\/web.facebook.com\/ttci.th\/\" \/>\n\t\t<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n\t\t<meta name=\"twitter:site\" content=\"@ttci_th\" \/>\n\t\t<meta name=\"twitter:title\" content=\"Antitumor activity of T cells secreting \u03b1CD133-\u03b1CD3 bispecific T-cell engager against cholangiocarcinoma\" \/>\n\t\t<meta name=\"twitter:description\" content=\"In a significant breakthrough for the treatment of cholangiocarcinoma (CCA), a highly lethal cancer of the bile duct epithelial cells,\" \/>\n\t\t<meta name=\"twitter:creator\" content=\"@ttci_th\" \/>\n\t\t<meta name=\"twitter:image\" content=\"https:\/\/www.ttci-th.org\/wp-content\/uploads\/2022\/03\/pexels-chokniti-khongchum-2280571-scaled.jpg\" \/>\n\t\t<script type=\"application\/ld+json\" class=\"aioseo-schema\">\n\t\t\t{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"BlogPosting\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\\\/#blogposting\",\"name\":\"Antitumor activity of T cells secreting \\u03b1CD133-\\u03b1CD3 bispecific T-cell engager against cholangiocarcinoma - Thailand Hub of Talents in Cancer Immunotherapy (TTCI Thailand)\",\"headline\":\"Antitumor activity of T cells secreting \\u03b1CD133-\\u03b1CD3 bispecific T-cell engager against cholangiocarcinoma\",\"author\":{\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/author\\\/admin\\\/#author\"},\"publisher\":{\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/#organization\"},\"image\":{\"@type\":\"ImageObject\",\"url\":\"https:\\\/\\\/www.ttci-th.org\\\/wp-content\\\/uploads\\\/2022\\\/03\\\/pexels-chokniti-khongchum-2280571-scaled.jpg\",\"width\":2560,\"height\":1709},\"datePublished\":\"2022-03-01T10:06:47+00:00\",\"dateModified\":\"2023-06-24T15:54:40+00:00\",\"inLanguage\":\"th\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\\\/#webpage\"},\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\\\/#webpage\"},\"articleSection\":\"Mahidol University, Mahidol University\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\\\/#breadcrumblist\",\"itemListElement\":[{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/#listItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/category\\\/research-news\\\/#listItem\",\"name\":\"Research News\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/category\\\/research-news\\\/#listItem\",\"position\":2,\"name\":\"Research News\",\"item\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/category\\\/research-news\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/category\\\/research-news\\\/research-news-research-news\\\/#listItem\",\"name\":\"Mahidol University\"},\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/#listItem\",\"name\":\"Home\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/category\\\/research-news\\\/research-news-research-news\\\/#listItem\",\"position\":3,\"name\":\"Mahidol University\",\"item\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/category\\\/research-news\\\/research-news-research-news\\\/\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\\\/#listItem\",\"name\":\"Antitumor activity of T cells secreting \\u03b1CD133-\\u03b1CD3 bispecific T-cell engager against cholangiocarcinoma\"},\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/category\\\/research-news\\\/#listItem\",\"name\":\"Research News\"}},{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\\\/#listItem\",\"position\":4,\"name\":\"Antitumor activity of T cells secreting \\u03b1CD133-\\u03b1CD3 bispecific T-cell engager against cholangiocarcinoma\",\"previousItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/category\\\/research-news\\\/research-news-research-news\\\/#listItem\",\"name\":\"Mahidol University\"}}]},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/#organization\",\"name\":\"Thailand Hub of Talents in Cancer Immunotherapy\",\"description\":\"TTCI-TH\",\"url\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"url\":\"https:\\\/\\\/www.ttci-th.org\\\/wp-content\\\/uploads\\\/2023\\\/05\\\/cropped-cropped-TTCI_LOGO__PNG_-001-removebg-preview.png\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\\\/#organizationLogo\",\"width\":512,\"height\":512},\"image\":{\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\\\/#organizationLogo\"},\"sameAs\":[\"https:\\\/\\\/web.facebook.com\\\/ttci.th\\\/\",\"https:\\\/\\\/www.twitter.com\\\/ttci_th\\\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/author\\\/admin\\\/#author\",\"url\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/author\\\/admin\\\/\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\\\/#authorImage\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/5b85cd0b211a9025509530deb5346a2678862327550dd3ffa569f013791940ac?s=96&d=mm&r=g\",\"width\":96,\"height\":96,\"caption\":\"admin\"}},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\\\/#webpage\",\"url\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\\\/\",\"name\":\"Antitumor activity of T cells secreting \\u03b1CD133-\\u03b1CD3 bispecific T-cell engager against cholangiocarcinoma - Thailand Hub of Talents in Cancer Immunotherapy (TTCI Thailand)\",\"description\":\"Photo by Chokniti Khongchum\\\/pexels In a significant breakthrough for the treatment of cholangiocarcinoma (CCA), a highly lethal cancer of the bile duct epithelial cells, researchers have developed a novel therapeutic option using engineered T cells. With limited treatment options and a high mortality rate associated with CCA, this research offers hope for improved outcomes and\",\"inLanguage\":\"th\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/#website\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\\\/#breadcrumblist\"},\"author\":{\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/author\\\/admin\\\/#author\"},\"creator\":{\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/author\\\/admin\\\/#author\"},\"image\":{\"@type\":\"ImageObject\",\"url\":\"https:\\\/\\\/www.ttci-th.org\\\/wp-content\\\/uploads\\\/2022\\\/03\\\/pexels-chokniti-khongchum-2280571-scaled.jpg\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\\\/#mainImage\",\"width\":2560,\"height\":1709},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\\\/#mainImage\"},\"datePublished\":\"2022-03-01T10:06:47+00:00\",\"dateModified\":\"2023-06-24T15:54:40+00:00\"},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/#website\",\"url\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/\",\"name\":\"Thailand Hub of Talents in Cancer Immunotherapy\",\"description\":\"TTCI-TH\",\"inLanguage\":\"th\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.ttci-th.org\\\/th\\\/#organization\"}}]}\n\t\t<\/script>\n\t\t<!-- All in One SEO -->\n\n","aioseo_head_json":{"title":"Antitumor activity of T cells secreting \u03b1CD133-\u03b1CD3 bispecific T-cell engager against cholangiocarcinoma - Thailand Hub of Talents in Cancer Immunotherapy (TTCI Thailand)","description":"Photo by Chokniti Khongchum\/pexels In a significant breakthrough for the treatment of cholangiocarcinoma (CCA), a highly lethal cancer of the bile duct epithelial cells, researchers have developed a novel therapeutic option using engineered T cells. With limited treatment options and a high mortality rate associated with CCA, this research offers hope for improved outcomes and","canonical_url":"https:\/\/www.ttci-th.org\/th\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\/","robots":"max-image-preview:large","keywords":"","webmasterTools":{"miscellaneous":""},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"BlogPosting","@id":"https:\/\/www.ttci-th.org\/th\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\/#blogposting","name":"Antitumor activity of T cells secreting \u03b1CD133-\u03b1CD3 bispecific T-cell engager against cholangiocarcinoma - Thailand Hub of Talents in Cancer Immunotherapy (TTCI Thailand)","headline":"Antitumor activity of T cells secreting \u03b1CD133-\u03b1CD3 bispecific T-cell engager against cholangiocarcinoma","author":{"@id":"https:\/\/www.ttci-th.org\/th\/author\/admin\/#author"},"publisher":{"@id":"https:\/\/www.ttci-th.org\/th\/#organization"},"image":{"@type":"ImageObject","url":"https:\/\/www.ttci-th.org\/wp-content\/uploads\/2022\/03\/pexels-chokniti-khongchum-2280571-scaled.jpg","width":2560,"height":1709},"datePublished":"2022-03-01T10:06:47+00:00","dateModified":"2023-06-24T15:54:40+00:00","inLanguage":"th","mainEntityOfPage":{"@id":"https:\/\/www.ttci-th.org\/th\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\/#webpage"},"isPartOf":{"@id":"https:\/\/www.ttci-th.org\/th\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\/#webpage"},"articleSection":"Mahidol University, Mahidol University"},{"@type":"BreadcrumbList","@id":"https:\/\/www.ttci-th.org\/th\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\/#breadcrumblist","itemListElement":[{"@type":"ListItem","@id":"https:\/\/www.ttci-th.org\/th\/#listItem","position":1,"name":"Home","item":"https:\/\/www.ttci-th.org\/th\/","nextItem":{"@type":"ListItem","@id":"https:\/\/www.ttci-th.org\/th\/category\/research-news\/#listItem","name":"Research News"}},{"@type":"ListItem","@id":"https:\/\/www.ttci-th.org\/th\/category\/research-news\/#listItem","position":2,"name":"Research News","item":"https:\/\/www.ttci-th.org\/th\/category\/research-news\/","nextItem":{"@type":"ListItem","@id":"https:\/\/www.ttci-th.org\/th\/category\/research-news\/research-news-research-news\/#listItem","name":"Mahidol University"},"previousItem":{"@type":"ListItem","@id":"https:\/\/www.ttci-th.org\/th\/#listItem","name":"Home"}},{"@type":"ListItem","@id":"https:\/\/www.ttci-th.org\/th\/category\/research-news\/research-news-research-news\/#listItem","position":3,"name":"Mahidol University","item":"https:\/\/www.ttci-th.org\/th\/category\/research-news\/research-news-research-news\/","nextItem":{"@type":"ListItem","@id":"https:\/\/www.ttci-th.org\/th\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\/#listItem","name":"Antitumor activity of T cells secreting \u03b1CD133-\u03b1CD3 bispecific T-cell engager against cholangiocarcinoma"},"previousItem":{"@type":"ListItem","@id":"https:\/\/www.ttci-th.org\/th\/category\/research-news\/#listItem","name":"Research News"}},{"@type":"ListItem","@id":"https:\/\/www.ttci-th.org\/th\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\/#listItem","position":4,"name":"Antitumor activity of T cells secreting \u03b1CD133-\u03b1CD3 bispecific T-cell engager against cholangiocarcinoma","previousItem":{"@type":"ListItem","@id":"https:\/\/www.ttci-th.org\/th\/category\/research-news\/research-news-research-news\/#listItem","name":"Mahidol University"}}]},{"@type":"Organization","@id":"https:\/\/www.ttci-th.org\/th\/#organization","name":"Thailand Hub of Talents in Cancer Immunotherapy","description":"TTCI-TH","url":"https:\/\/www.ttci-th.org\/th\/","logo":{"@type":"ImageObject","url":"https:\/\/www.ttci-th.org\/wp-content\/uploads\/2023\/05\/cropped-cropped-TTCI_LOGO__PNG_-001-removebg-preview.png","@id":"https:\/\/www.ttci-th.org\/th\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\/#organizationLogo","width":512,"height":512},"image":{"@id":"https:\/\/www.ttci-th.org\/th\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\/#organizationLogo"},"sameAs":["https:\/\/web.facebook.com\/ttci.th\/","https:\/\/www.twitter.com\/ttci_th\/"]},{"@type":"Person","@id":"https:\/\/www.ttci-th.org\/th\/author\/admin\/#author","url":"https:\/\/www.ttci-th.org\/th\/author\/admin\/","name":"admin","image":{"@type":"ImageObject","@id":"https:\/\/www.ttci-th.org\/th\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\/#authorImage","url":"https:\/\/secure.gravatar.com\/avatar\/5b85cd0b211a9025509530deb5346a2678862327550dd3ffa569f013791940ac?s=96&d=mm&r=g","width":96,"height":96,"caption":"admin"}},{"@type":"WebPage","@id":"https:\/\/www.ttci-th.org\/th\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\/#webpage","url":"https:\/\/www.ttci-th.org\/th\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\/","name":"Antitumor activity of T cells secreting \u03b1CD133-\u03b1CD3 bispecific T-cell engager against cholangiocarcinoma - Thailand Hub of Talents in Cancer Immunotherapy (TTCI Thailand)","description":"Photo by Chokniti Khongchum\/pexels In a significant breakthrough for the treatment of cholangiocarcinoma (CCA), a highly lethal cancer of the bile duct epithelial cells, researchers have developed a novel therapeutic option using engineered T cells. With limited treatment options and a high mortality rate associated with CCA, this research offers hope for improved outcomes and","inLanguage":"th","isPartOf":{"@id":"https:\/\/www.ttci-th.org\/th\/#website"},"breadcrumb":{"@id":"https:\/\/www.ttci-th.org\/th\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\/#breadcrumblist"},"author":{"@id":"https:\/\/www.ttci-th.org\/th\/author\/admin\/#author"},"creator":{"@id":"https:\/\/www.ttci-th.org\/th\/author\/admin\/#author"},"image":{"@type":"ImageObject","url":"https:\/\/www.ttci-th.org\/wp-content\/uploads\/2022\/03\/pexels-chokniti-khongchum-2280571-scaled.jpg","@id":"https:\/\/www.ttci-th.org\/th\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\/#mainImage","width":2560,"height":1709},"primaryImageOfPage":{"@id":"https:\/\/www.ttci-th.org\/th\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\/#mainImage"},"datePublished":"2022-03-01T10:06:47+00:00","dateModified":"2023-06-24T15:54:40+00:00"},{"@type":"WebSite","@id":"https:\/\/www.ttci-th.org\/th\/#website","url":"https:\/\/www.ttci-th.org\/th\/","name":"Thailand Hub of Talents in Cancer Immunotherapy","description":"TTCI-TH","inLanguage":"th","publisher":{"@id":"https:\/\/www.ttci-th.org\/th\/#organization"}}]},"og:locale":"th_TH","og:site_name":"Thailand Hub of Talents in Cancer Immunotherapy (TTCI Thailand) - TTCI-TH","og:type":"article","og:title":"Antitumor activity of T cells secreting \u03b1CD133-\u03b1CD3 bispecific T-cell engager against cholangiocarcinoma","og:description":"In a significant breakthrough for the treatment of cholangiocarcinoma (CCA), a highly lethal cancer of the bile duct epithelial cells,","og:url":"https:\/\/www.ttci-th.org\/th\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\/","og:image":"https:\/\/www.ttci-th.org\/wp-content\/uploads\/2022\/03\/pexels-chokniti-khongchum-2280571-scaled.jpg","og:image:secure_url":"https:\/\/www.ttci-th.org\/wp-content\/uploads\/2022\/03\/pexels-chokniti-khongchum-2280571-scaled.jpg","og:image:width":"2560","og:image:height":"1709","article:published_time":"2022-03-01T10:06:47+00:00","article:modified_time":"2023-06-24T15:54:40+00:00","article:publisher":"https:\/\/web.facebook.com\/ttci.th\/","twitter:card":"summary_large_image","twitter:site":"@ttci_th","twitter:title":"Antitumor activity of T cells secreting \u03b1CD133-\u03b1CD3 bispecific T-cell engager against cholangiocarcinoma","twitter:description":"In a significant breakthrough for the treatment of cholangiocarcinoma (CCA), a highly lethal cancer of the bile duct epithelial cells,","twitter:creator":"@ttci_th","twitter:image":"https:\/\/www.ttci-th.org\/wp-content\/uploads\/2022\/03\/pexels-chokniti-khongchum-2280571-scaled.jpg"},"aioseo_meta_data":{"post_id":"14450","title":null,"description":null,"keywords":[],"keyphrases":{"focus":{"keyphrase":"T-cell engager against ","score":76,"analysis":{"keyphraseInTitle":{"score":9,"maxScore":9,"error":0},"keyphraseInDescription":{"score":9,"maxScore":9,"error":0},"keyphraseLength":{"score":9,"maxScore":9,"error":0,"length":3},"keyphraseInURL":{"score":5,"maxScore":5,"error":0},"keyphraseInIntroduction":{"score":3,"maxScore":9,"error":1},"keyphraseInSubHeadings":{"score":3,"maxScore":9,"error":1},"keyphraseInImageAlt":[]}},"additional":[]},"primary_term":null,"canonical_url":null,"og_title":"#post_title","og_description":"In a significant breakthrough for the treatment of cholangiocarcinoma (CCA), a highly lethal cancer of the bile duct epithelial cells,","og_object_type":"default","og_image_type":"featured","og_image_url":"https:\/\/www.ttci-th.org\/wp-content\/uploads\/2022\/03\/pexels-chokniti-khongchum-2280571-scaled.jpg","og_image_width":"2560","og_image_height":"1709","og_image_custom_url":null,"og_image_custom_fields":null,"og_video":"","og_custom_url":null,"og_article_section":null,"og_article_tags":[],"twitter_use_og":false,"twitter_card":"default","twitter_image_type":"featured","twitter_image_url":"https:\/\/www.ttci-th.org\/wp-content\/uploads\/2022\/03\/pexels-chokniti-khongchum-2280571-scaled.jpg","twitter_image_custom_url":null,"twitter_image_custom_fields":null,"twitter_title":"#post_title","twitter_description":"In a significant breakthrough for the treatment of cholangiocarcinoma (CCA), a highly lethal cancer of the bile duct epithelial cells,","schema":{"blockGraphs":[],"customGraphs":[],"default":{"data":{"Article":[],"Course":[],"Dataset":[],"FAQPage":[],"Movie":[],"Person":[],"Product":[],"ProductReview":[],"Car":[],"Recipe":[],"Service":[],"SoftwareApplication":[],"WebPage":[]},"graphName":"","isEnabled":true},"graphs":[]},"schema_type":"default","schema_type_options":null,"pillar_content":false,"robots_default":true,"robots_noindex":false,"robots_noarchive":false,"robots_nosnippet":false,"robots_nofollow":false,"robots_noimageindex":false,"robots_noodp":false,"robots_notranslate":false,"robots_max_snippet":"-1","robots_max_videopreview":"-1","robots_max_imagepreview":"large","priority":0,"frequency":"default","local_seo":null,"limit_modified_date":false,"created":"2023-06-09 10:16:15","updated":"2026-09-03 06:47:04","focus_keyword":"T-cell engager against","additional_keywords":null,"truseo_locale":null,"ai":null,"breadcrumb_settings":null,"seo_analyzer_scan_date":null},"aioseo_breadcrumb":"<div class=\"aioseo-breadcrumbs\"><span class=\"aioseo-breadcrumb\">\n\t\t\t<a href=\"https:\/\/www.ttci-th.org\/th\/\" title=\"Home\">Home<\/a>\n\t\t<\/span><span class=\"aioseo-breadcrumb-separator\">\u00bb<\/span><span class=\"aioseo-breadcrumb\">\n\t\t\t<a href=\"https:\/\/www.ttci-th.org\/th\/category\/research-news\/\" title=\"Research News\">Research News<\/a>\n\t\t<\/span><span class=\"aioseo-breadcrumb-separator\">\u00bb<\/span><span class=\"aioseo-breadcrumb\">\n\t\t\t<a href=\"https:\/\/www.ttci-th.org\/th\/category\/research-news\/research-news-research-news\/\" title=\"Mahidol University\">Mahidol University<\/a>\n\t\t<\/span><span class=\"aioseo-breadcrumb-separator\">\u00bb<\/span><span class=\"aioseo-breadcrumb\">\n\t\t\tAntitumor activity of T cells secreting \u03b1CD133-\u03b1CD3 bispecific T-cell engager against cholangiocarcinoma\n\t\t<\/span><\/div>","aioseo_breadcrumb_json":[{"label":"Home","link":"https:\/\/www.ttci-th.org\/th\/"},{"label":"Research News","link":"https:\/\/www.ttci-th.org\/th\/category\/research-news\/"},{"label":"Mahidol University","link":"https:\/\/www.ttci-th.org\/th\/category\/research-news\/research-news-research-news\/"},{"label":"Antitumor activity of T cells secreting \u03b1CD133-\u03b1CD3 bispecific T-cell engager against cholangiocarcinoma","link":"https:\/\/www.ttci-th.org\/th\/antitumor-activity-of-t-cells-secreting-%ce%b1cd133-%ce%b1cd3-bispecific-t-cell-engager-against-cholangiocarcinoma\/"}],"_links":{"self":[{"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/posts\/14450","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/comments?post=14450"}],"version-history":[{"count":0,"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/posts\/14450\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/media\/14452"}],"wp:attachment":[{"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/media?parent=14450"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/categories?post=14450"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/tags?post=14450"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}