{"id":20781,"date":"2025-01-07T03:40:53","date_gmt":"2025-01-07T03:40:53","guid":{"rendered":"https:\/\/www.ttci-th.org\/?p=20781"},"modified":"2025-03-16T03:50:44","modified_gmt":"2025-03-16T03:50:44","slug":"optimizing-human-therapeutic-antibodies-2","status":"publish","type":"post","link":"https:\/\/www.ttci-th.org\/th\/optimizing-human-therapeutic-antibodies-2\/","title":{"rendered":"Optimizing Humanness of Therapeutic Antibodies"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"20781\" class=\"elementor elementor-20781\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-32163b7 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"32163b7\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9247286\" data-id=\"9247286\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-31ef166 elementor-widget elementor-widget-text-editor\" data-id=\"31ef166\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.16.0 - 14-09-2023 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>Scientists have been working to improve therapeutic antibodies, which are important tools for treating diseases like cancer and autoimmune disorders. A key challenge is making these antibodies less likely to be rejected by the patient&#8217;s immune system. In this study, researchers used a computer-based approach to modify the structure of an antibody to make it look more like a human antibody. They then used other computer simulations to check if these changes would affect how well the antibody binds to its target. The results showed that while they could improve how human-like the antibody was, this sometimes came at the cost of reducing its ability to bind effectively. This highlights the delicate balance scientists must strike when designing therapeutic antibodies.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6e75882 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"6e75882\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-16220c7\" data-id=\"16220c7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0386e6f elementor-widget elementor-widget-spacer\" data-id=\"0386e6f\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.16.0 - 14-09-2023 *\/\n.elementor-column .elementor-spacer-inner{height:var(--spacer-size)}.e-con{--container-widget-width:100%}.e-con-inner>.elementor-widget-spacer,.e-con>.elementor-widget-spacer{width:var(--container-widget-width,var(--spacer-size));--align-self:var(--container-widget-align-self,initial);--flex-shrink:0}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container,.e-con>.elementor-widget-spacer>.elementor-widget-container{height:100%;width:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer{height:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner{height:var(--container-widget-height,var(--spacer-size))}.e-con-inner>.elementor-widget-spacer.elementor-widget-empty,.e-con>.elementor-widget-spacer.elementor-widget-empty{position:relative;min-height:22px;min-width:22px}.e-con-inner>.elementor-widget-spacer.elementor-widget-empty .elementor-widget-empty-icon,.e-con>.elementor-widget-spacer.elementor-widget-empty .elementor-widget-empty-icon{position:absolute;top:0;bottom:0;left:0;right:0;margin:auto;padding:0;width:22px;height:22px}<\/style>\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-cb58e40 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"cb58e40\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-22372e9\" data-id=\"22372e9\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d30471e elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"d30471e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.16.0 - 14-09-2023 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">\u0e40\u0e07\u0e34\u0e19\u0e17\u0e38\u0e19<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6aeec7e elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"6aeec7e\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.16.0 - 14-09-2023 *\/\n.elementor-widget-divider{--divider-border-style:none;--divider-border-width:1px;--divider-color:#0c0d0e;--divider-icon-size:20px;--divider-element-spacing:10px;--divider-pattern-height:24px;--divider-pattern-size:20px;--divider-pattern-url:none;--divider-pattern-repeat:repeat-x}.elementor-widget-divider .elementor-divider{display:flex}.elementor-widget-divider .elementor-divider__text{font-size:15px;line-height:1;max-width:95%}.elementor-widget-divider .elementor-divider__element{margin:0 var(--divider-element-spacing);flex-shrink:0}.elementor-widget-divider .elementor-icon{font-size:var(--divider-icon-size)}.elementor-widget-divider .elementor-divider-separator{display:flex;margin:0;direction:ltr}.elementor-widget-divider--view-line_icon .elementor-divider-separator,.elementor-widget-divider--view-line_text .elementor-divider-separator{align-items:center}.elementor-widget-divider--view-line_icon .elementor-divider-separator:after,.elementor-widget-divider--view-line_icon .elementor-divider-separator:before,.elementor-widget-divider--view-line_text .elementor-divider-separator:after,.elementor-widget-divider--view-line_text .elementor-divider-separator:before{display:block;content:\"\";border-bottom:0;flex-grow:1;border-top:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--element-align-left .elementor-divider .elementor-divider-separator>.elementor-divider__svg:first-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-left .elementor-divider-separator:before{content:none}.elementor-widget-divider--element-align-left .elementor-divider__element{margin-left:0}.elementor-widget-divider--element-align-right .elementor-divider .elementor-divider-separator>.elementor-divider__svg:last-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-right .elementor-divider-separator:after{content:none}.elementor-widget-divider--element-align-right .elementor-divider__element{margin-right:0}.elementor-widget-divider:not(.elementor-widget-divider--view-line_text):not(.elementor-widget-divider--view-line_icon) .elementor-divider-separator{border-top:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--separator-type-pattern{--divider-border-style:none}.elementor-widget-divider--separator-type-pattern.elementor-widget-divider--view-line .elementor-divider-separator,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:after,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:before,.elementor-widget-divider--separator-type-pattern:not([class*=elementor-widget-divider--view]) .elementor-divider-separator{width:100%;min-height:var(--divider-pattern-height);-webkit-mask-size:var(--divider-pattern-size) 100%;mask-size:var(--divider-pattern-size) 100%;-webkit-mask-repeat:var(--divider-pattern-repeat);mask-repeat:var(--divider-pattern-repeat);background-color:var(--divider-color);-webkit-mask-image:var(--divider-pattern-url);mask-image:var(--divider-pattern-url)}.elementor-widget-divider--no-spacing{--divider-pattern-size:auto}.elementor-widget-divider--bg-round{--divider-pattern-repeat:round}.rtl .elementor-widget-divider .elementor-divider__text{direction:rtl}.e-con-inner>.elementor-widget-divider,.e-con>.elementor-widget-divider{width:var(--container-widget-width,100%);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-86b218e elementor-widget elementor-widget-text-editor\" data-id=\"86b218e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>This research was supported by Chiang Mai University and Fundamental Fund 2024.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-513a232 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"513a232\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7709a77\" data-id=\"7709a77\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1fc1ca7 elementor-widget elementor-widget-spacer\" data-id=\"1fc1ca7\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f5f587e elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"f5f587e\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-03bcea0\" data-id=\"03bcea0\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ca5ef47 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"ca5ef47\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\n\u0e01\u0e23\u0e30\u0e14\u0e32\u0e29\u0e15\u0e49\u0e19\u0e09\u0e1a\u0e31\u0e1a<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2a9807c elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"2a9807c\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-89bfba8 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"89bfba8\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>\u0e0a\u0e37\u0e48\u0e2d\u0e1a\u0e17\u0e04\u0e27\u0e32\u0e21\u0e15\u0e49\u0e19\u0e09\u0e1a\u0e31\u0e1a:<\/strong> Plasticity of BioPhi-driven humanness optimization in ScFv-CD99 binding affinity validated through AlphaFold, HADDOCK, and MD simulations.<br \/><strong>\u0e27\u0e32\u0e23\u0e2a\u0e32\u0e23:<\/strong> Computational and Structural Biotechnology Journal<br \/><strong>\u0e14\u0e2d\u0e22: <\/strong><a href=\"https:\/\/doi.org\/10.1016\/j.csbj.2025.01.001\">https:\/\/doi.org\/10.1016\/j.csbj.2025.01.001<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2cc934e elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"2cc934e\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9bf8d38\" data-id=\"9bf8d38\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4b1861f elementor-widget elementor-widget-spacer\" data-id=\"4b1861f\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5c5d082 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"5c5d082\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d7e3d8d\" data-id=\"d7e3d8d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8a45000 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"8a45000\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u0e08\u0e14\u0e2b\u0e21\u0e32\u0e22\u0e42\u0e15\u0e49\u0e15\u0e2d\u0e1a<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6aa3269 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"6aa3269\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8df055a elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"8df055a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul><li>Kanokporn Sornsuwan (<a href=\"mailto:kanokporn.sornsuwan@cmu.ac.th\">kanokporn.sornsuwan@cmu.ac.th<\/a>)<\/li><li>Thanathat Pamonsupornwichit (<a href=\"mailto:thanathat.pamon@cmu.ac.th\">thanathat.pamon@cmu.ac.th<\/a>)<\/li><li>On-anong Juntit (<a href=\"mailto:Onanong.j@cmu.ac.th\">Onanong.j@cmu.ac.th<\/a>)<\/li><li>Weeraya Thongkum (<a href=\"mailto:weeraya.t@cmu.ac.th\">weeraya.t@cmu.ac.th<\/a>)<\/li><li>Nuchjira Takheaw (<a href=\"mailto:nuchjira.t@cmu.ac.th\">nuchjira.t@cmu.ac.th<\/a>)<\/li><li>Kanchanok Kodchakorn (<a href=\"mailto:kanchanok.k@cmu.ac.th\">kanchanok.k@cmu.ac.th<\/a>)<\/li><li>Chatchai Tayapiwatana (<a href=\"mailto:chatchai.t@cmu.ac.th\">chatchai.t@cmu.ac.th<\/a>)<\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a2a0cb4 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no\" data-id=\"a2a0cb4\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8067b9b\" data-id=\"8067b9b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-235d100 elementor-widget elementor-widget-jkit_social_share\" data-id=\"235d100\" data-element_type=\"widget\" data-widget_type=\"jkit_social_share.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div  class=\"jeg-elementor-kit jkit-social-share jeg_module___69e60b0009024\" ><ul class=\"social-share-list\"><li class=\"elementor-repeater-item-14d1b21\" data-social=\"facebook\">\n\t\t\t\t<a class=\"facebook social-icon\"><span class=\"icon-position-before\"><i aria-hidden=\"true\" class=\"fab fa-facebook-f\"><\/i>\u0e40\u0e1f\u0e2a\u0e1a\u0e38\u0e4a\u0e04<\/span><\/a>\n\t\t\t<\/li><li class=\"elementor-repeater-item-ee9a855\" data-social=\"twitter\">\n\t\t\t\t<a class=\"twitter social-icon\"><span class=\"icon-position-before\"><i aria-hidden=\"true\" class=\"fab fa-twitter\"><\/i>\u0e17\u0e27\u0e34\u0e15\u0e40\u0e15\u0e2d\u0e23\u0e4c<\/span><\/a>\n\t\t\t<\/li><li class=\"elementor-repeater-item-4a6d796\" data-social=\"line\">\n\t\t\t\t<a class=\"line social-icon\"><span class=\"icon-position-before\"><i aria-hidden=\"true\" class=\"fab fa-line\"><\/i>\u0e40\u0e2a\u0e49\u0e19<\/span><\/a>\n\t\t\t<\/li><\/ul><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Scientists have been working to improve therapeutic antibodies, which are important tools for treating diseases like cancer and autoimmune disorders. A key challenge is making these antibodies less likely to be rejected by the patient&#8217;s immune system. In this study, researchers used a computer-based approach to modify the structure of an antibody to make it&#8230;<\/p>","protected":false},"author":4,"featured_media":20345,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[178],"tags":[180],"class_list":["post-20781","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-news-cmu","tag-tag-topic-cmu"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/posts\/20781","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/comments?post=20781"}],"version-history":[{"count":0,"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/posts\/20781\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/media\/20345"}],"wp:attachment":[{"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/media?parent=20781"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/categories?post=20781"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ttci-th.org\/th\/wp-json\/wp\/v2\/tags?post=20781"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}