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Carcinoma-associated fibroblasts (CAFs) secrete IL-6-induced doxorubicin (Dox) resistance and PD-L1 expression through STAT3 and AKT pathways, play a critical role in breast cancer progression and reduce folate receptor alpha (FRα)-CAR T cell function. Target either blocking IL-6/IL-6R signaling or PD-1/PDL1 inhibitors may serve as a therapeutics that may be combined to improve the response to CAR-T cell treatment and Dox treatment in TNBC patients.
Funding
- Mid-Research Grant (N42A650343) funded by the National Research Council of Thailand and Mahidol University
- Siriraj Research Fund, Faculty of Medicine Siriraj Hospital, Mahidol University (Grant Number: R016532012)
Original Paper
Title of original paper: Enhancement of PD-L1-attenuated CAR-T cell function through breast cancer-associated fibroblasts-derived IL-6 signaling via STAT3/AKT pathways
Journal:Breast Cancer Res
DOI: 10.1186/s13058-023-01684-7