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S100 calcium-binding protein A2 (S100A2) which has been proposed as a potential marker in many types of cancer, however, the prognostic value of S100A2 in colorectal cancer (CRC) is rarely reported. The immunohistochemistry, bulk RNA transcriptomic data and multiplex immunofluorescence (mIF) showed low cytoplasmic protein expression of S100A2 in the tumour core was associated with poor survival and with tumour-relating signaling and infiltrating immune cells in CRC.
Funding
- Mazumdar-Shaw chair fund and UKRI: Enabling integrated diagnostics for early detection: 42497: Integrated Technologies for Improved Polyp Surveillance (INCISE)
- Cancer Research UK Scotland Centre (CTRQQR-2021\100006)
New Researcher Grant, Mahidol University (grant no. R016420006)
Original Paper
Title of original paper: Protein expression of S100A2 reveals its association with patient prognosis and immune infiltration profile in colorectal cancer
Journal: J Cancer
DOI: 10.7150/jca.83910
Correspondence
Joanne Edwards