Researchers have developed a new approach to T cell therapy that is more effective in killing triple-negative breast cancer (TNBC) cells. This new approach uses a combination of peptides to activate T cells to target and kill cancer cells. The researchers found that this approach was more effective than traditional T cell therapy. This is good news for patients with TNBC, as it could lead to more effective treatments.
Funding
This work was supported by the Siriraj Research Fund, Faculty of Medicine Siriraj Hospital, Mahidol University (R016334002 and R016737004).
Original Paper
Title of original paper: Mesothelin- and nucleolin-specific T cells from combined short peptides effectively kill triple-negative breast cancer cells
Journal: BMC Medicine
DOI: https://doi.org/10.1186/s12916-024-03625-3