- A new study has shown promising results for the use of fourth-generation CAR-T cell therapy in the treatment of breast cancer.
- CAR-T cell therapy involves genetically modifying a patient’s own immune cells to recognize and attack cancer cells.
- This approach has been successful in treating certain blood cancers, but its application to solid tumors like breast cancer has been challenging.
- The new study found that fourth-generation CAR-T cells were more effective at killing breast cancer cells than previous generations of CAR-T cells.
- The researchers are now planning to test this approach in clinical trials.
Funding
- Thailand Research Fund (TRF)
- Center of Excellence on Medical Biotechnology (CEMB)
- Mahidol University
- Siriraj Chalermphrakiat Grants
Original Paper
Title of original paper: Cytotoxicity of fourth-generation anti-Trop2 CAR-T cells against breast cancer
Journal: International Immunopharmacology
DOI: https://doi.org/10.1016/j.intimp.2024.111631