- Researchers have developed a new approach to stimulate T cell responses against breast cancer cells.
- The researchers identified neoantigens, which are unique markers found on cancer cells, from patient-derived breast cancer cells.
- They then loaded these neoantigens onto peripheral blood mononuclear cells (PBMCs), which are a type of immune cell.
- The neoantigen-loaded PBMCs were able to stimulate T cells to attack and kill the breast cancer cells.
- This approach could lead to the development of new, personalized cancer vaccines.
Funding
- National Research Council of Thailand
- Siriraj Research Grant, Faculty of Medicine Siriraj Hospital, Mahidol University
Original Paper
Title of original paper: Stimulating T cell responses against patient-derived breast cancer cells with neoantigen peptide-loaded peripheral blood mononuclear cells
Journal: Cancer Immunology, Immunotherapy
DOI: https://doi.org/10.1007/s00262-024-03627-3