Scientists Develop More Powerful Cancer-Fighting Cells
Scientists have created a new type of immune cell, called a CAR-T cell, that’s even better at fighting multiple myeloma, a type of blood cancer. These new cells are designed to target a specific protein on cancer cells, called BCMA.
Previous CAR-T cells have shown promise in treating multiple myeloma, but they can sometimes be less effective over time. The new CAR-T cells, however, are more potent and can better eliminate cancer cells, even those with lower levels of the BCMA protein. This breakthrough could lead to more effective treatments for patients with multiple myeloma who haven’t responded to other therapies.
Funding
Open access funding provided by Mahidol University. This work was supported by the Mahidol University’s Basic Research Fund (Fiscal Year 2022) under grant [number BRF1-029/2565]; the Siriraj Research Fund of the Faculty of Medicine Siriraj Hospital, Mahidol University under grant [number R016034008]. Additionally, PR was supported by the National Science and Technology Development Agency (NSTDA) awarded a Royal Thai Government Scholarship. TS was supported by Mahidol University (New Discovery and Frontier Research). MJ was supported by Siriraj Chalermphrakiat Grants. Finally, JS was supported by Mahidol University Grants and the Office of National Higher Education Science Research and Innovation Policy Council (NXPO) through the Program Management Unit-Competitiveness (PMU-C) under grant [number C10F630063]. PL, JS, MJ, and PY are members of the Thailand Hub of Talents in Cancer Immunotherapy (TTCI). The academic endeavors of TTCI receive support from the National Research Council of Thailand (NRCT) under grant [number N35E660102].
Original Paper
Title of original paper: Therapeutic Potential of Third-Generation Chimeric Antigen Receptor T Cells Targeting B Cell Maturation Antigen for Treating Multiple Myeloma
Journal: Clinical and Experimental Medicine
DOI: https://doi.org/10.1007/s10238-024-01347-7
Correspondence
Dr. Mutita Junking, Email: [email protected]
Dr. Pa-thai Yenchitsomanus, Email: [email protected]