Scientists have developed a new way to improve CAR T-cell therapy for blood cancers. CAR T-cell therapy involves genetically modifying a patient’s T cells to recognize and attack cancer...
Researchers have discovered that cordycepin and an extract from the Cordyceps militaris mushroom can make cancer cells more vulnerable to destruction by the immune system. The researchers found that...
Researchers have developed a new approach to T cell therapy that is more effective in killing triple-negative breast cancer (TNBC) cells. This new approach uses a combination of peptides...
Scientists have developed a new method to better predict which peptides (small proteins) can effectively bind to specific HLA molecules. HLA molecules are like display cases on cells that...
This study compared different CAR T cell designs and found that using a CD8α spacer and tumor necrosis factor receptor (TNFR)-based costimulation (4-1BB or CD27) enhanced the treatment’s efficacy....
Scientists have developed a new type of immunotherapy that uses genetically modified natural killer (NK) cells to target and destroy cancer cells. NK cells are a type of immune...
Scientists have engineered immune cells to be more effective at fighting T-cell leukemia. They modified these cells to lack a protein called CD147, which altered their behavior and showed...
Scientists have developed a new approach to enhance T cell therapies for cholangiocarcinoma (CCA), a type of cancer that originates in the bile ducts. The researchers armed T cells,...
CD99, which is highly expressed in T-acute lymphoblastic leukemia (T-ALL), could be an effective target for antibody-based treatment. In this study, researchers used a monoclonal antibody against CD99 called...
Scientists have developed a new and improved chimeric antigen receptor (CAR) T-cell therapy for multiple myeloma, a type of blood cancer. 1 This new therapy uses a third-generation CAR...