ทีมจุฬาลงกรณ์มหาวิทยาลัย

คุณสมบัติ

• D.D.S., Ph.D.

ชื่อเรื่องและสังกัด

• Associate Professor Department of Microbiology, Faculty of Dentistry, Chulalongkorn University

คำอธิบายสั้น ๆ ของการทำงานร่วมกัน 

• Dendritic cells are a diverse group of specialized antigen-presenting cells that have the bidirectional ability to initiate and dictate immunity toward immune activation and immune tolerance. Immunogenic dendritic cells, which are primarily induced by pathogens and inflammatory mediators, typically promote the effector function of adaptive immune cells. On the other hand, tolerogenic DCs, which are induced by either anti-inflammatory mediators or signals that interfere with immunogenic dendritic cell function, play a critical role in induction of immune tolerance, resolution of ongoing immune responses, and prevention of autoimmunity by inhibiting effector and autoreactive T cells, and by triggering regulatory T cell development. The major advantages of dendritic cells are their ability to induce antigen-specific immunity that presumably is less adverse effect, and their potential to mediate the memory response that helps to prevent the disease recurrence. Therefore, improvement of DC properties is promising, but challenges remain. Our laboratory studies dendritic cell immunobiology and aims to harness dendritic cells ex vivo and in situ to treat immune-related diseases, including sepsis, autoimmune diseases, and cancer. Research in the Ritprajak laboratory determines the molecular mechanisms of dendritic cells that contribute to human diseases and exploits our discovery for the prevention and treatment of immune-related diseases.

อีเมล: [email protected]
ลิงค์: https://www.dent.chula.ac.th/en/teams/patcharee-ritprajak/